A systematic review of how patients value COPD outcomes

The European Respiratory Journal
Yuan ZhangHolger J Schünemann

Abstract

Our objective was to summarise systematically all research evidence related to how patients value outcomes in chronic obstructive pulmonary disease (COPD).We conducted a systematic review (systematic review registration number CRD42015015206) by searching PubMed, Embase, PsycInfo and CINAHL, and included reports that assessed the relative importance of outcomes from COPD patients' perspective. Two authors independently determined the eligibility of studies, abstracted the eligible studies and assessed risk of bias. We narratively summarised eligible studies, meta-analysed utilities for individual outcomes and assessed the certainty of evidence using the Grading of Recommendations, Assessment, Development and Evaluations approach.We included 217 quantitative studies. Investigators most commonly used utility measurements of outcomes (n=136), discrete choice exercises (n=13), probability trade-off (n=4) and forced choice techniques (n=46). Patients rated adverse events as important but on average, less so than symptom relief. Exacerbation and hospitalisation due to exacerbation are the outcomes that COPD patients rate as most important. This systematic review provides a comprehensive registry of related studies.

References

Jan 13, 1996·BMJ : British Medical Journal·D L SackettW S Richardson
Jun 2, 2000·BMJ : British Medical Journal·M Ryan, S Farrar
Jan 31, 2004·BMJ : British Medical Journal·Mark SculpherMark Emberton
Feb 14, 2004·BMJ : British Medical Journal·Mandy Ryan
Sep 13, 2005·Health and Quality of Life Outcomes·Elisabeth StåhlBo Lundbäck
Oct 6, 2005·The European Respiratory Journal·J HaughneyC-G Löfdahl
Aug 30, 2006·Respiratory Medicine·Marc MiravitllesMatthias Fargel
Jan 2, 2007·Respiratory Medicine·Yogesh Suresh PunekarMichael Spencer
May 10, 2007·PharmacoEconomics·A Simon PickardAndrew Lloyd
May 16, 2007·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Karen E BremnerMurray D Krahn
Jun 20, 2007·International Journal of Clinical Practice·J F O'ReillyL Rice
Aug 24, 2007·The European Respiratory Journal·J BourbeauG Ruberto
Sep 4, 2007·Lancet·David M Mannino, A Sonia Buist
Jan 9, 2008·Respiratory Medicine·A Simon PickardTodd A Lee
Aug 22, 2008·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Graeme M RockerUNKNOWN Canadian Researchers at the End of Life Network
Aug 30, 2008·Journal of Pain and Symptom Management·Lois DowneyDonald L Patrick
Dec 24, 2008·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·A SzendeK Svensson
Apr 28, 2009·International Journal of Clinical Practice·J M Rodriguez Gonzalez-MoroA Martín
Jan 7, 2011·Journal of Clinical Epidemiology·Howard BalshemGordon H Guyatt
Jan 14, 2011·Respiratory Medicine·Marc MiravitllesUNKNOWN ESFERA investigators
Mar 16, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Helen J StarkiePaul Jones
Mar 29, 2011·Respiratory Medicine·Lucas M A GoossensMaureen P M H Rutten-van Mölken
Apr 20, 2011·Health and Quality of Life Outcomes·A Simon PickardTodd A Lee
Jun 11, 2011·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Martyn R PartridgeDario Olivieri
Oct 13, 2011·PharmacoEconomics·Jennifer PetrilloMaureen Rutten-van Mölken
Dec 27, 2011·Archivos de bronconeumología·Bernardino AlcázarMarc Miravitlles
Jan 10, 2013·The American Journal of Hospice & Palliative Care·Lynn F ReinkeDavid H Au
Apr 26, 2013·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Paul HernandezShannon L Walker
Jul 19, 2013·International Journal of Technology Assessment in Health Care·Ann-Sylvia BrookerMurray Krahn
Oct 2, 2013·PharmacoEconomics·Susan M JoyJohn F P Bridges
Dec 18, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Holger J SchünemannElie A Akl

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Citations

Sep 18, 2018·The European Respiratory Journal·Gary T FergusonPaul Dorinsky
Oct 2, 2019·International Journal of Clinical Practice·Francisco-Javier Gonzalez-BarcalaFrancisco-Javier Salgado
May 6, 2020·The European Respiratory Journal·James D ChalmersMarc Miravitlles
Apr 9, 2019·American Journal of Respiratory and Critical Care Medicine·Wassim W LabakiSurya P Bhatt
Jul 4, 2020·The European Respiratory Journal·Alexander G MathioudakisUNKNOWN DECODE-NET (DisEntangling Chronic Obstructive pulmonary Disease Exacerbations clinical trials NETwork) Investigators
Sep 29, 2020·ERJ Open Research·John R HurstC Michael Roberts
Nov 24, 2020·Expert Review of Respiratory Medicine·Ana MachadoChris Burtin
Jan 15, 2021·Thorax·Daryl O Cheng, John R Hurst
Mar 31, 2021·Annals of the American Thoracic Society·David M MacDonaldKen M Kunisaki

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