A Systematic Review of miR-29 in Cancer

Molecular Therapy Oncolytics
Jason J KwonJanaiah Kota

Abstract

MicroRNAs (miRNA) are small non-coding RNAs (∼22 nt in length) that are known as potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a critical role in cancer pathogenesis, and the misregulation of miRNAs is a well-known feature of cancer. In recent years, miR-29 has emerged as a critical miRNA in various cancers, and it has been shown to regulate multiple oncogenic processes, including epigenetics, proteostasis, metabolism, proliferation, apoptosis, metastasis, fibrosis, angiogenesis, and immunomodulation. Although miR-29 has been thoroughly documented as a tumor suppressor in the majority of studies, some controversy remains with conflicting reports of miR-29 as an oncogene. In this review, we provide a systematic overview of miR-29's functional role in various mechanisms of cancer and introspection on the contradictory roles of miR-29.

Citations

Nov 7, 2019·Cells·Marcela Cristina RobainaClaudete Esteves Klumb
Jun 5, 2020·Antioxidants·Álvaro García-GuedeInmaculada Ibáñez-de-Caceres
Sep 1, 2020·Journal of Cancer Research and Clinical Oncology·I-Peng ChenRüdiger Greinert
May 5, 2020·Endocrine Reviews·Md Soriful IslamJames Segars
Nov 7, 2019·International Journal of Molecular Sciences·Mirza Muhammad Fahd QadirRicardo Luis Pastori
Mar 21, 2020·Cell Death Discovery·Massimiliano AgostiniGerry Melino
Aug 17, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Tsai-Der ChuangVirender K Rehan
Jul 14, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Oto InoueMasayuki Takamura
Sep 12, 2020·Cancers·Iwona SidorkiewiczAdam Krętowski
Sep 11, 2020·International Journal of Molecular Sciences·Linsey J F PetersEmiel P C van der Vorst
Sep 10, 2020·Journal of Clinical Medicine·Burcin ÖzdirikChristoph Roderburg
Mar 21, 2020·Frontiers in Oncology·Ying XiangShuai-Shuai Niu
Dec 15, 2020·Briefings in Bioinformatics·Elham KazemiKawsar Ahmed
Dec 12, 2020·Critical Reviews in Oncology/hematology·Hussein SabitManel Esteller
Dec 1, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shuai ZhouHui Chun Liu
Feb 13, 2021·Cancers·Asahiro MorishitaTsutomu Masaki
Jan 26, 2021·Frontiers in Cardiovascular Medicine·Masood Abu-HalimaTanja Raedle-Hurst
Feb 6, 2021·International Journal of Molecular Sciences·Raphael MohrChristoph Roderburg
Nov 12, 2020·International Journal of Molecular Sciences·Kyoko OuraTsutomu Masaki
Feb 20, 2021·Journal of Exposure Science & Environmental Epidemiology·Alesia M JungJefferey L Burgess
Feb 11, 2021·Cell Death Discovery·Massimiliano AgostiniGerry Melino
Mar 9, 2021·Frontiers in Microbiology·Urbi MukhopadhyayAnupam Mukherjee
Apr 4, 2021·Biomedicines·Pinelopi I ArtemakiChristos K Kontos
Apr 30, 2021·Saudi Journal of Biological Sciences·Bader Alshehri
Jun 26, 2021·Molecular Therapy. Nucleic Acids·Hongxiang LiShiwei Duan
Jun 15, 2021·Frontiers in Pharmacology·Vishal JhanjiGary Hin-Fai Yam
Jul 18, 2021·Journal of Neuropathology and Experimental Neurology·Greta FoianiMaria Teresa Mandara

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Datasets Mentioned

BETA
GSE12452
GSE14738
GSE44861

Methods Mentioned

BETA
transgenic
xenograft
acetylation
surgical resection
GTPase
biopsies

Clinical Trials Mentioned

NCT01543074
NCT01486277
NCT01351415
NCT01863693
NCT01239732
NCT02475213
NCT02603224

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