A Systematic Review of Placental Biomarkers Predicting Small-for-Gestational-Age Neonates

Biological Research for Nursing
Rungnapa RuchobAleeca F Bell

Abstract

Neonates born small for gestational age (SGA) face increased risk of neonatal mortality, childhood developmental problems, and adult disease. The placenta is a key factor in SGA development because of its multiple biological processes that underlie fetal growth. However, valid and reliable placental biomarkers of SGA have not been determined. The objective of this article was to systematically identify and review studies examining associations between placental biomarkers and SGA and assess those biomarkers' predictive value. Use of the matrix method and the PRISMA guidelines ensured systematic identification of relevant articles based on selection criteria. PubMed, CINAHL, and EMBASE were searched for English articles published in 2005-2016 that addressed relationships between placental biomarkers and SGA. The search captured 466 articles; 13 met selection criteria. The review identified 14 potential placental biomarkers for SGA, with placental growth factor and soluble fms-like tyrosine kinase 1 being the most commonly studied. However, findings for these and other biomarkers have often been contradictory. Thus, no placental biomarkers have been confirmed as reliable for predicting SGA. The inconsistent findings suggest low p...Continue Reading

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Citations

Jan 27, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Stephanie Chassen, Thomas Jansson
Aug 7, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Chileshe M Mabula-BwalyaJoan T Price

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BETA
SGA
ELISA

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QUADAS

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