A systematic review of population pharmacokinetic analyses of digoxin in the paediatric population.

British Journal of Clinical Pharmacology
Mariam H Abdel JalilKhawla Abu-Hammour

Abstract

This is a PROSPERO registered systematic review (CRD42018105207), conducted to summarize the available knowledge regarding the population pharmacokinetics of digoxin in paediatrics and to identify the sources of variability in its disposition. PubMed, ISI Web of Science, SCOPUS and Science Direct databases were searched from inception to January 2019. All paediatric population pharmacokinetic studies of digoxin that utilized the nonlinear mixed-effect modelling approach were incorporated in this review, and data were synthesized descriptively. After application of the inclusion-exclusion criteria 8 studies were included. Most studies described digoxin pharmacokinetics as a 1-compartment model with only 1 study describing its pharmacokinetics as 2-compartments. Age was an important predictor of clearance in studies involving neonates or infants, other predictors of clearance were weight, height, serum creatinine, coadministration of spironolactone and presence of congestive heart failure. Congestive heart failure was also associated with an increased volume of distribution in 1 study. The estimated value of apparent clearance in a typical individual standardized by mean weight ranged between 0.24 and 0.56 L/h/kg, the interindivi...Continue Reading

References

Jan 1, 1977·Clinical Pharmacokinetics·G Wettrell, K E Andersson
Jan 1, 1992·Clinical Pharmacokinetics·P J WilliamsM Kamigaki
Jan 1, 1985·European Journal of Clinical Pharmacology·M A NaafsJ Silberbusch
Sep 1, 1974·Acta paediatrica Scandinavica·G WettrellN R Lundström
Jun 1, 1982·American Heart Journal·M Artman, T P Graham
Jul 1, 1980·European Journal of Clinical Pharmacology·L Nyberg, G Wettrell
Feb 20, 1997·The New England Journal of Medicine·UNKNOWN Digitalis Investigation Group
Sep 13, 2000·The Journal of Allergy and Clinical Immunology·G L Kearns
Nov 9, 2002·American Journal of Therapeutics·Ehab S EL DesokyHartmut Derendorf
Nov 27, 2002·Therapeutic Drug Monitoring·A Martín-SuárezJ M Lanao
Sep 19, 2003·The New England Journal of Medicine·Gregory L KearnsRalph E Kauffman
Jun 30, 2006·European Journal of Pediatrics·Brian J AndersonNicholas H G Holford
Jul 20, 2007·Journal of Clinical Pharmacy and Therapeutics·E YukawaM Minemoto
Aug 23, 2007·British Journal of Clinical Pharmacology·C DartoisP Girard
Jul 2, 2010·Journal of Clinical Pharmacology·Miho YukawaMasao Mimemoto
Jul 1, 2009·Annals of Pediatric Cardiology·Shreepal Jain, Balu Vaidyanathan
Nov 3, 2010·Paediatric Anaesthesia·Alison H Thomson, Henry L Elliott
Oct 13, 2011·Critical Pathways in Cardiology·Michael EhleRobert P Giugliano
Oct 26, 2012·European Journal of Drug Metabolism and Pharmacokinetics·Rong ChenZong-ling Xia
Feb 20, 2013·Clinical Pharmacokinetics·Stefanie HennigAlison H Thomson
Dec 19, 2013·American Journal of Perinatology·Emily M HsiehUNKNOWN Best Pharmaceuticals for Children Act—Pediatric Trials Network
May 20, 2014·Journal of Pharmacological Sciences·Yan GongZhiping Li
Aug 12, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Richard KirkRobert Weintraub
Feb 1, 2015·Clinical Pharmacokinetics·Salmaan KanjiDavid Moher
Sep 1, 2015·BMJ : British Medical Journal·Graham D Cole, Darrel P Francis
Jan 13, 2016·Journal of the American Heart Association·David W BrownUNKNOWN National Pediatric Cardiology Quality Improvement Collaborative
Mar 10, 2016·Cardiology·Dimitrios M KonstantinouGeorge Giannakoulas
Mar 24, 2016·Antimicrobial Agents and Chemotherapy·Celeste BloomfieldStefanie Hennig

❮ Previous
Next ❯

Citations

Oct 21, 2020·European Journal of Clinical Pharmacology·Janthima Methaneethorn, Nattawut Leelakanok
Feb 23, 2021·European Journal of Drug Metabolism and Pharmacokinetics·Mariam Abdel JalilKhawla Abu-Hammour
May 8, 2021·International Immunopharmacology·Jian Lynn LeeShamin Mohd Saffian
Oct 17, 2020·Seizure : the Journal of the British Epilepsy Association·Janthima Methaneethorn, Nattawut Leelakanok

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.