A Systematic Review of Renal Health in Healthy Individuals Associated with Protein Intake above the US Recommended Daily Allowance in Randomized Controlled Trials and Observational Studies

Advances in Nutrition
Mary E Van ElswykShalene H McNeill

Abstract

A systematic review was used to identify randomized controlled trials (RCTs) and observational epidemiologic studies (OBSs) that examined protein intake consistent with either the US RDA (0.8 g/kg or 10-15% of energy) or a higher protein intake (≥20% but <35% of energy or ≥10% higher than a comparison intake) and reported measures of kidney function. Studies (n = 26) of healthy, free-living adults (>18 y old) with or without metabolic disease risk factors were included. Studies of subjects with overt disease, such as chronic kidney, end-stage renal disease, cancer, or organ transplant, were excluded. The most commonly reported variable was glomerular filtration rate (GFR), with 13 RCTs comparing GFRs obtained with normal and higher protein intakes. Most (n = 8), but not all (n = 5), RCTs reported significantly higher GFRs in response to increased protein intake, and all rates were consistent with normal kidney function in healthy adults. The evidence from the current review is limited and inconsistent with regard to the role of protein intake and the risk of kidney stones. Increased protein intake had little or no effect on blood markers of kidney function. Evidence reported here suggests that protein intake above the US RDA ha...Continue Reading

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Citations

Dec 7, 2018·International Journal of Sport Nutrition and Exercise Metabolism·Oliver C WitardStuart M Phillips
Jul 16, 2020·Advances in Nutrition·Stuart M PhillipsDonald K Layman
Jun 3, 2020·Pediatric Gastroenterology, Hepatology & Nutrition·Helen H WangDavid Q-H Wang
Jul 3, 2020·Clinical Interventions in Aging·Wolfgang KemmlerRobert Kob
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Jun 1, 2021·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Golaleh AsghariFereidoun Azizi
Jul 25, 2021·International Journal of Environmental Research and Public Health·Irina ChernukhaDaniil Khvostov

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