A systematic review of safety and efficacy of hepatopancreatoduodenectomy for biliary and gallbladder cancers

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Yan-Ming ZhouBin Li

Abstract

To review the evidence on the safety and efficacy of hepatopancreatoduodenectomy for biliary and gallbladder cancers. Medline and EMBASE were systematically searched for papers of hepatopancreatoduodenectomy in patients with biliary and gallbladder cancers. Eighteen studies involving 397 patients were reviewed. Major hepatectomy was undertaken in 81.3% of the 397 patients and the R0 resection rate was 71.3%. The morbidity and mortality rates were 78.9% and 10.3%, respectively. The 5-year overall survival rate ranged from 3% to 50% (median = 31%). The 5-year survival rate in patients who underwent curative resection was 18-68.8% (median = 51.3%), and 0% in patients who received non-curative resection. Hepatopancreatoduodenectomy is a challenging procedure with high morbidity and mortality rates. However, this procedure can provide a chance of long-term survival in patients in whom curative resection is feasible.

References

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Citations

Dec 23, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jian WangWan-Guang Zhang
Jan 20, 2018·Langenbeck's Archives of Surgery·F RassamT M van Gulik
Apr 22, 2017·World Journal of Gastroenterology : WJG·Zong-Ming ZhangYue Zhao
Sep 7, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Naokazu ChibaShigeyuki Kawachi
Dec 26, 2018·The British Journal of Surgery·K SøreideS J Wigmore
Apr 6, 2020·Annals of Surgical Oncology·Calogero IaconoAlfredo Guglielmi
Feb 4, 2021·Current Problems in Surgery·T Peter KinghamMichael I D'Angelica
Jan 4, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Melroy A D'SouzaUNKNOWN E-AHPBA scientific and research committee

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