A systematic review of salvage focal therapies for localised non-metastatic radiorecurrent prostate cancer

Translational Andrology and Urology
Christopher C KhooTaimur Tariq Shah

Abstract

Although radiotherapy to the prostate for cancer is effective, recurrence occurs in 10-15% within 5 years. Traditional salvage treatments for men with radiorecurrent prostate cancer comprise of watchful waiting (WW) with or without androgen deprivation therapy (ADT) or radical prostatectomy (RP). Neither strategy provides ideal therapeutic ratios. Salvage focal ablation is an emerging option. We performed a systematic review of the Medline and Embase databases for studies reporting outcomes of focal salvage brachytherapy (sBT), cryotherapy (sCT) or high-intensity focused ultrasound (sHIFU) for radiorecurrent prostate cancer (conception to April 2019). Results were screened for inclusion against predetermined eligibility criteria. Certain data were extracted, including rates of biochemical disease-free survival (BDFS), metastasis, conversion to second-line therapies and adverse events. Of a total 134 articles returned from the search, 15 studies (14 case series and 1 comparative study) reported outcomes after focal sBT [5], sCT [7] and sHIFU [3]. Cohort size varied depending on intervention, with eligible studies of sBT being small case series. Median follow-up ranged from 10 to 56 months. Although pre-salvage demographics were ...Continue Reading

Citations

Mar 5, 2021·Current Opinion in Urology·Derek J LomasLance A Mynderse
Jul 1, 2021·The Journal of International Medical Research·Na YuGuangming Niu
Jul 30, 2021·Frontiers in Surgery·Arnas RakauskasMassimo Valerio

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