A systematic review of studies of DNA methylation in the context of a weight loss intervention

Epigenomics
Lucia AronicaMegan P Hitchins

Abstract

Obesity results from the interaction of genetic and environmental factors, which may involve epigenetic mechanisms such as DNA methylation (DNAm). We have followed the PRISMA protocol to select studies that analyzed DNAm at baseline and end point of a weight loss intervention using either candidate-locus or genome-wide approaches. Six genes displayed weight loss associated DNAm across four out of nine genome-wide studies. Weight loss is associated with significant but small changes in DNAm across the genome, and weight loss outcome is associated with individual differences in baseline DNAm at several genomic locations. The identified weight loss associated DNAm markers, especially those showing reproducibility across different studies, warrant validation by further studies with robust design and adequate power.

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Citations

Apr 13, 2018·Clinical Epigenetics·Tomi AkinyemijuMarguerite R Irvin
Feb 27, 2018·Psychopathology·Edward D Barker
Feb 12, 2019·Molecular Psychiatry·Mari Sild, Linda Booij
May 20, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Xiang LiLu Qi
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Apr 3, 2020·Nature Reviews. Endocrinology·Rodrigo San-CristobalJosé Alfredo Martínez
Jul 2, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Haruhiko NishidaYutaka Kimura
Sep 25, 2020·Clinical Epigenetics·Cristina Gallardo-EscribanoM Rosa Bernal-Lopez
Aug 8, 2021·International Journal of Molecular Sciences·Andrea RossnerovaPavel Rossner

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Methods Mentioned

BETA
PCR
methylation profiling
gastric bypass
RRBS

Software Mentioned

EpiTYPER
MassARRAY EpiTYPER
HGNChelper R package
R
BioMaRt R
Covidence
EWAS

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