A Systematic Review of Surgical Randomized Controlled Trials: Part I. Risk of Bias and Outcomes: Common Pitfalls Plastic Surgeons Can Overcome

Plastic and Reconstructive Surgery
Sophocles H VoineskosMohit Bhandari

Abstract

The authors investigated the methodological validity of plastic surgery randomized controlled trials that compared surgical interventions. An electronic search identified randomized controlled trials published between 2000 and 2013. Reviewers, independently and in duplicate, assessed manuscripts and performed data extraction. Methodological safeguards (randomization, allocation concealment, blinding, and incomplete outcome data) were examined using the Cochrane risk of bias tool. Regression analysis was used to identify trial characteristics associated with risk of bias. Of 1664 potentially eligible studies, 173 randomized controlled trials were included. Proper randomization and allocation concealment methods were described in 61 of 173 (35 percent) and 21 of 173 (12 percent), respectively. Outcome assessors were blinded in 58 of 173 (34 percent) trials, and patients were blinded in 45 of 173 (26 percent). Follow-up rates were high, with 99 of 173 (57 percent) randomized controlled trials appearing to have complete follow-up. An intention-to-treat analysis was used in 19 of 173 (11 percent) trials. One-third (58 of 173, 34 percent) did not state their primary outcomes. The most common type of primary outcome used was a symptom...Continue Reading

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Citations

Sep 25, 2017·Plastic and Reconstructive Surgery·Osama A SamargandiMichael Bezuhly
Jun 25, 2017·Neurosurgery·Tej D AzadGerald A Grant
Jun 14, 2018·The Journal of Hand Surgery, European Volume·Chao LongPaige M Fox
Jun 13, 2019·Plastic and Reconstructive Surgery·Connor McGuireMichael Bezuhly
Oct 15, 2019·The Journal of Bone and Joint Surgery. American Volume·Edward J HarveyJulie Agel
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Jun 18, 2016·Plastic and Reconstructive Surgery·Matthew D Gardiner, Abhilash Jain
Jul 1, 2020·Aesthetic Surgery Journal·Achilles ThomaFelmont F Eaves
May 22, 2020·Journal of Neurological Surgery. Part A, Central European Neurosurgery·Rodrigo Panico GorayebJoaquim José Ferreira
Jan 26, 2017·Plastic and Reconstructive Surgery·Sophocles H VoineskosMohit Bhandari
Jul 28, 2019·Plastic and Reconstructive Surgery·Connor McGuireMichael Bezuhly
Feb 8, 2018·Annual Review of Medicine·Sophocles H VoineskosAndrea L Pusic
Jan 8, 2021·Aesthetic Plastic Surgery·Osama A SamargandiLujain Mirdad

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