A systematic review of the effect of HIV infection and antiretroviral therapy on the risk of pre-eclampsia

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Joëlla W AdamsB Ryan Phelps

Abstract

The associations between HIV infection, antiretroviral therapy (ART), and pre-eclampsia are unclear. To summarize research and clarify the implications of HIV and ART on pre-eclampsia risk. MedLine, PubMed, Web of Science, and the Cochrane Library were searched for studies published between 2003 and July 2014, using relevant keywords. Full-text review was dependent on the inclusion of pre-eclampsia as an outcome and original data. Data for population, confounders, limitations, and measures of association were qualitatively assessed. Among 550 records identified, 70 were screened, and 13 were included. Five of the nine studies comparing pre-eclampsia risk between women with and without HIV infection found no significant difference; only one found that women living with HIV were more likely to experience pre-eclampsia. Two studies found that women living with HIV who were receiving ART at conception were more likely to experience pre-eclampsia than were those not receiving ART at conception. Two studies reported that pre-eclampsia rates did not differ by ART regimen. There is insufficient evidence to conclude that women living with HIV and receiving ART have a higher risk of pre-eclampsia than do women without HIV infection; furt...Continue Reading

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Citations

Nov 17, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K GiannakouS I Papatheodorou
Sep 30, 2018·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R TownsendUNKNOWN IPPIC Network
Jan 26, 2018·PloS One·Maria StougaardBerit Lilienthal Heitmann
Jun 4, 2020·Paediatric and Perinatal Epidemiology·Angela M BengtsonLandon Myer
Apr 28, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yazira PillayThajasvarie Naicker
Dec 15, 2016·Frontiers in Medicine·Douglas B Kell, Louise C Kenny
Feb 9, 2020·Progress in Cardiovascular Diseases·Samson OkelloMark J Siedner
Feb 16, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Joan T PriceJeffrey S A Stringer

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