A systematic review of the effects of CYP2D6 phenotypes on risperidone treatment in children and adolescents

Child and Adolescent Psychiatry and Mental Health
Thomas DodsworthAlasdair M Barr

Abstract

The second generation antipsychotic drug risperidone is widely used in the field of child and adolescent psychiatry to treat conditions associated with disruptive behavior, aggression and irritability, such as autism spectrum disorders. While risperidone can provide symptomatic relief for many patients, there is considerable individual variability in the therapeutic response and side-effect profile of the medication. One well established biological factor that contributes to these individual differences is genetic variation in the cytochrome P450 enzyme 2D6. The 2D6 enzyme metabolizes risperidone and therefore affects drug levels and dosing. In the present review, we summarize the current literature on 2D6 variants and their effects on risperidone responses, specifically in children and adolescents. Relevant articles were identified through systematic review, and after irrelevant articles were discarded, ten studies were included in the review. Most prospective studies were well controlled, but often did not have a large enough sample size to make robust statements about rarer variants, including those categorized as ultra-rapid and poor metabolizers. Individual studies demonstrated a role for different genetic variants in risp...Continue Reading

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Citations

Feb 6, 2020·The Pharmacogenomics Journal·Maria Stella CalafatoElvira Bramon
Oct 20, 2020·Journal of Child and Adolescent Psychopharmacology·Abdullah Al MarufChad Bousman
Apr 27, 2021·Expert Opinion on Drug Metabolism & Toxicology·Jacob T BrownJeffrey R Bishop

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Methods Mentioned

BETA
genotyping

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