A systematic review of the influence of radiation-induced lymphopenia on survival outcomes in solid tumors

Critical Reviews in Oncology/hematology
Bhanu Prasad VenkatesuluSunil Krishnan

Abstract

Lymphopenia is a common accompaniment of multimodal cancer therapy. As the most radiosensitive cells of the hematopoietic system, lymphocytes residing within or circulating through a radiation portal are frequently depleted by radiation therapy. The recognition that radiation-induced reduction of circulating lymphocyte counts and eventual lymphocyte infiltration of tumors have a tangible impact on overall survival outcomes has revived the interest in understanding the causes of treatment-associated lymphopenia and developing strategies to predict, prevent and ameliorate this well-documented phenomenon. In this systematic review, we have performed a comprehensive search of the literature to elucidate the studies that document a correlation between radiation-associated lymphopenia and survival outcomes in solid malignancies. We also summarize potential unifying paradigms that account for radiation-induced lymphopenia across studies and lay the groundwork for attempting to explain and/or counter this phenomenon.

Citations

Dec 19, 2018·Cancers·Shang-Jui Wang, Bruce Haffty
Jul 19, 2019·The British Journal of Radiology·Marco Durante, Silvia Formenti
Jan 17, 2020·The British Journal of Radiology·F Avraham DilmanianSunil Krishnan
Sep 3, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Hyunwoo ParkDuk-Hee Lee
Sep 29, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tanguy Y Seiwert, Ana P Kiess
Mar 30, 2019·Journal for Immunotherapy of Cancer·Christine Ménétrier-CauxChristophe Caux
Apr 2, 2020·Radiation Oncology Journal·Changhee KangEun Kyung Choi
Jan 8, 2019·F1000Research·Bhanu Prasad VenkatesuluSunil Krishnan
Apr 15, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·K HolubA Biete
Oct 22, 2020·Cancers·Walter Tinganelli, Marco Durante
Oct 2, 2020·International Journal of Radiation Oncology, Biology, Physics·Laura E EwingIgor Koturbash
Dec 16, 2020·International Journal of Radiation Oncology, Biology, Physics·Hwa Kyung ByunJinsil Seong
Sep 12, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Xiaoxue XieTing Xu
Nov 2, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Emre YekedüzYüksel Ürün
Jan 28, 2021·International Journal of Molecular Sciences·Noel E DonlonJoanne Lysaght
Nov 28, 2020·International Journal of Radiation Oncology, Biology, Physics·Kevin X LiuShannon M MacDonald
Aug 11, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·E JouglarS Supiot
Aug 17, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·S-L WongR Mendes
Jan 10, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Stanislav LazarevCharles B Simone
Jan 14, 2021·JNCI Cancer Spectrum·Bhanu P VenkatesuluSunil Krishnan

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