A systematic review of the literature of the three related disease entities cheilitis granulomatosa, orofacial granulomatosis and Melkersson - Rosenthal syndrome

Current Pediatric Reviews
Goetz Wehl, Markus Rauchenzauner

Abstract

Melkersson Rosenthal syndrome (MRS) is a rare disorder of unknown etiology and comprises the triad: orofacial edema, recurrent facial paralysis and lingua plicata. In the current literature confusing heterogeneity exists, mixing together the historically grown terms cheilitis granulomatosa or granulomatous cheilitis, Melkersson Rosenthal syndrome and the umbrella term orofacial granulomatosis (OFG). We provide a systematic review comprising all three disease entities of orofacial granulomatosis using the computerized database "Pubmed Medline" entering the key words "orofacial granulomatosis" (141 references), "Melkersson-Rosenthal syndrome" (207 references), "granulomatous cheilitis" or "cheilitis granulomatosa" (102 references) back to 1956. Full text journals and case studies were included, and data synthesis was performed individually. Etiology remains unclear for all three disease entities. Etiological relatedness to chronic inflammatory bowel disease is under discussion and effectiveness was found for different treatments, e.g. local triamcinolone injections, antibiotics, surgical interventions, TNF alpha blockers or exclusive enteral nutrition. No randomized controlled trial concerning the therapy of orofacial granulomato...Continue Reading

Citations

Sep 10, 2019·International Journal of Dermatology·Alexandre GueutierMahtab Samimi
Nov 26, 2019·The American Journal of Dermatopathology·Irena E BelousovaDmitry V Kazakov
Mar 13, 2020·International Journal of General Medicine·Sumeet R DhawanPratibha D Singhi
Jul 2, 2020·Clinical, Cosmetic and Investigational Dentistry·Ronald BrownDonna Grant-Mills
Jul 6, 2020·Oral and Maxillofacial Surgery·Abhilasha YadavSuhas Jajoo
Nov 12, 2020·JAMA Dermatology·Joseph S DurginMisha Rosenbach
Oct 27, 2020·Maxillofacial Plastic and Reconstructive Surgery·Massimo PorriniFrancesco Spadari
Feb 24, 2021·Journal of the American Academy of Dermatology·Frédéric JaouenMahtab Samimi
Apr 29, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Jonathan PeterMark Davis
Dec 1, 2019·Annals of Dermatology·Seung Ju YunJong Soo Hong
Apr 23, 2021·Actas dermo-sifiliográficas·J Aróstegui AguilarA Fernandez-Flores
Jun 13, 2021·BMJ Case Reports·Anuradha PavuluriUmesh Narsinghani
Jul 27, 2021·Frontiers in Medicine·Marc A Judson

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