A systematic review of the prevalence of depression, anxiety, and apathy in frontotemporal dementia, atypical and young-onset Alzheimer's disease, and inherited dementia

International Psychogeriatrics
Jessica D CollinsAida Suárez-González

Abstract

Depression, anxiety, and apathy are the most commonly reported neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD). Understanding their prevalence in rarer dementias such as frontotemporal dementia (FTD), primary progressive aphasia (PPA), posterior cortical atrophy (PCA), young-onset AD (YOAD), and inherited dementias has implications for both clinical practice and research. In this study, we aimed to examine the current state of knowledge of the prevalence of these three NPS in less prevalent dementias. We conducted a systematic review based on searches of EMBASE, PsycINFO, and PubMed up to September 2019. 47 articles meeting inclusion criteria were identified. Depression, anxiety, and apathy were commonly reported across the phenotypes studied but their prevalence showed large variation between studies. Apathy showed the highest reported frequency in FTD (50-100% across studies), behavioral variant frontotemporal dementia (bvFTD) (73-100%), and YOAD (44-100%). Anxiety was frequently reported in FTD (0-100%) and bvFTD (19-63%). Depression showed the highest prevalence in FTD (7-69%) and YOAD (11-55%). Among the three variants of PPA, sv-PPA is the one most investigated (seven articles). Three or fewer articles were id...Continue Reading

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Citations

Mar 16, 2021·Frontiers in Psychiatry·Luis Agüera-OrtizJesús Porta-Etessam
Jun 1, 2021·Frontiers in Psychiatry·Ping WangJianren Liu
Jun 18, 2021·Frontiers in Pharmacology·Manuel Enrique Machado-DuqueJorge Enrique Machado-Alba

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