PMID: 11907921Mar 23, 2002Paper

A systematic review of the skeletal effects of estrogen therapy in postmenopausal women. I. An assessment of the quality of randomized trials published between 1977 and 1995

Climacteric : the Journal of the International Menopause Society
D HenryW Gillespie

Abstract

To examine the quality of published randomized controlled trials of the effects of estrogen treatment on fracture risk and measures of bone mass. Articles on estrogen treatment for osteoporosis published between 1977 and 1995 were identified by searching Medline and Excerpta Medica databases and bibliographies of original papers and published reviews. Studies selected were randomized controlled trials of the efficacy of estrogens in preventing loss of bone mass or fractures in postmenopausal women. Data extraction and quality assessment were performed in duplicate, with assistance of a manual. Raters were blinded as to authors and their affiliations and the publication details. Of 99 eligible randomized controlled trials published between 1977 and 1995, eight included no extractable data, and 23 contained results that were published in duplicate. Total quality scores increased over time, but this was accounted for by improvements only in the measurement technologies used to estimate bone mineral content or density. There was no improvement in the quality of randomization methods, the extent to which withdrawals were accounted for, or in the baseline comparability of treated and control patients. Neither sample sizes nor duratio...Continue Reading

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Citations

Apr 23, 2010·Expert Opinion on Pharmacotherapy·Susan R Davis, Fiona Jane
Mar 23, 2002·Climacteric : the Journal of the International Menopause Society·D O'ConnellW Gillespie
Mar 20, 2004·Internal Medicine Journal·L M Rivera-Woll, S R Davis
Oct 4, 2005·Journal of the American Academy of Dermatology·Glenda Hall, Tania J Phillips
Oct 28, 2006·Gynäkologisch-geburtshilfliche Rundschau·M Schmidt, R Kimmig

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