A Systematic Review of Ultrasound-Detected Lipohypertrophy in Insulin-Exposed People with Diabetes

Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders
Haya Abu GhazalehHenrietta Mulnier

Abstract

Lipohypertrophy (LH) is a common complication occurring in diabetes individuals. The most common methods used include palpation, visual examination and/or ultrasound (US). To date, there is limited information on the detection sensitivity among the different techniques used to identify LH. This systematic review aimed to identify studies that examined insulin-related LH using US detection to identify the prevalence, characteristics and morphology of LH, and to compare US and clinical palpation methods for detecting LH. Three electronic databases were systematically searched for studies detecting LH using US in insulin users. Articles were screened for eligibility and included studies were appraised using quality assessment tools. The quality of the evidence was evaluated using Grading of Recommendations Assessment, Development and Evaluation, and the extracted data was synthesised narratively. Sixteen articles were included in the review providing data on 1722 patients. The prevalence of LH prevalence varied from 14.5% to 88% (median 56.6%). Identified risk factors for the development of included insulin injection behaviour such as a lack of injection site rotation and social factors such as low education level. Four studies co...Continue Reading

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Citations

Jul 20, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Sandro GentileUNKNOWN AMD-OSDI Study Group on Injection Techniques and Nefrocenter Research & Nyx Start-up Study Group
Aug 19, 2020·Chinese Medical Journal·Xiao-Han XuZi-Lin Sun
Dec 8, 2020·Journal of Diabetes and Its Complications·Dan LuoTao Yang
Aug 29, 2021·Endocrinología, Diabetes Y Nutrición·Fatma Nur KorkmazSevim Güllü

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