A systematic review of urinary bladder hypertrophy in experimental diabetes: Part 2. Comparison of animal models and functional consequences

Neurourology and Urodynamics
Johanne H EllenbroekMartin C Michel

Abstract

To explore whether the bladder hypertrophy consistently seen in rats upon streptozotocin injection also occurs in other animal models of type 1 or 2 diabetes and how hypertrophy is linked to functional alterations of the urinary bladder. A systematic search for the key word combination "diabetes," "bladder," and "hypertrophy" was performed in PubMed; additional references were identified from reference lists of those publications. All papers were systematically extracted for relevant information. Models other than streptozotocin-injected rats and female animals have been poorly studied. Most animal models of diabetes exhibit less bladder hypertrophy as compared to streptozotocin-injected rats. However, this is not linked to type 1 versus 2 diabetes models, and type 2 models with comparable elevation of blood glucose may exhibit strong or only minor hypertrophy. Bladder dysfunction is frequently observed in experimental diabetes and mostly manifests as increased compliance but does not segregate with hypertrophy. It may at least partly reflect the need to handle large amounts of urine in models associated with major elevation of blood glucose. To better understand the relevance of bladder hypertrophy in many models of experiment...Continue Reading

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Citations

Feb 10, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Martin C Michel
Sep 19, 2019·Oxidative Medicine and Cellular Longevity·Igor BlahaMedardo Hernández
Sep 3, 2019·Frontiers in Pharmacology·Zeynep Elif YesilyurtEbru Arioglu-Inan
Jun 27, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Betül R ErdoganMartin C Michel
Mar 20, 2021·The Journal of Pharmacy and Pharmacology·Nadire EserMustafa Cicek
Apr 2, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Martin C Michel, Ebru Arioglu-Inan

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