A systematic review of xuezhikang, an extract from red yeast rice, for coronary heart disease complicated by dyslipidemia.

Evidence-based Complementary and Alternative Medicine : ECAM
Qinghua ShangJianping Liu

Abstract

Objective. This systematic review aims to evaluate the benefit and side effect of Xuezhikang for coronary heart disease (CHD) complicated by dyslipidemia. Methods. All randomized clinical trials (RCTs) with Xuezhikang as a treatment for CHD combined with dyslipidemia were considered for inclusion. Data extraction and analyses and quality assessment were conducted according to the Cochrane standards. Results. We included 22 randomized trials. Xuezhikang showed significant benefit on the incidence of all-cause deaths, CHD deaths, myocardial infarction, and revascularization as compared with placebo based on conventional treatment for CHD. It remarkably lowered total cholesterol (TC), triglyceride (TG), and low-density lipoprotein-cholesterol (LDL-C) as compared with the placebo or inositol nicotinate group, which was similar to statins group. Xuezhikang also raised high-density lipoprotein cholesterol (HDL-C) compared to placebo or no intervention, which was similar to Inositol nicotinate and slightly inferior to statins. The incidence of adverse events did not differ between the Xuezhikang and control group. Conclusions. Xuezhikang showed a comprehensive lipid-regulating effect and was safe and effective in reducing cardiovascul...Continue Reading

References

May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Feb 12, 2005·Internal Medicine·Maiko SakaiRyuzo Ueda
Jun 28, 2006·Chinese Journal of Integrative Medicine·Zong-liang LuShui-ping Zhao
Jun 30, 2011·European Heart Journal·UNKNOWN European Association for Cardiovascular Prevention & RehabilitationUNKNOWN ESC Committee for Practice Guidelines (CPG) 2008-2010 and 2010-2012 Committees

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Citations

Dec 12, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Chia-Hao ChenChun-Jung Lin
Jan 29, 2013·International Journal of Pharmaceutics·Chia-Hao ChenChun-Jung Lin
Mar 10, 2016·Journal of Clinical Pharmacy and Therapeutics·Yi Chin Ong, Zoriah Aziz
Apr 4, 2016·World Journal of Microbiology & Biotechnology·Seema Patel
Sep 5, 2014·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Jiangquan LiaoJinhang Du
Apr 2, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Ming GuoDa-Zhuo Shi
Mar 19, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Shi-Peng ZhuXiao-Hong Li
May 20, 2016·Phytotherapy Research : PTR·Ji Young LeeChang Gue Son
Jul 24, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Gerard E Mullin
Mar 18, 2021·Praxis·Monika RauBeat Knechtle
Apr 7, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Licai LiangPeng Sun

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

Revman
CCSPS

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