A systematic review on mutation markers for bladder cancer diagnosis in urine.

BJU International
Anouk E HentschelJakko A Nieuwenhuijzen

Abstract

To systematically summarise the available evidence on urinary bladder cancer (BC) mutation markers. Gene mutations are expected to provide novel biomarkers for urinary BC diagnosis. To date, evidence on urinary BC mutation markers has not proven sufficient to be adopted by clinical guidelines. In the present systematic review, diagnostic accuracy of urinary mutation analysis is separately assessed for primary BC diagnosis (BC detection) and for follow-up of BC patients (BC surveillance). A literature search (PubMed, Embase.com and Wiley/Cochrane Library) and systematic review was performed up to 31 October 2019. As studies were too heterogeneous, no quantitative analysis could be performed. In total, 25 studies were summarised by qualitative analysis. For BC detection, diagnostic accuracy differed considerably for single mutation markers (sensitivity 1-85%, specificity 84-100%), and for marker panels (sensitivity 50-94%, specificity 43-97%). Similarly, for BC surveillance, diagnostic accuracy was highly variable for single mutation markers (sensitivity 0-85%, specificity 66-100%), and for marker panels (sensitivity 51-84%, specificity 66-96%). Urinary mutation analysis showed to be a promising diagnostic tool for non-invasive B...Continue Reading

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Methods Mentioned

BETA
GTPase
PCR
electrophoresis
biopsies
biopsy

Software Mentioned

Quality Assessment of Diagnostic Accuracy Studies ( QUADAS ) 2
Review Manager
QUADAS

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