A systematic review on the genotoxic effect of serotonin and norepinephrine reuptake inhibitors (SNRIs) antidepressants

Psychopharmacology
Mahnaz AhmadimaneshRezvan Yazdian-Robati

Abstract

Depression is a major mental disorder affecting millions of people worldwide. Serotonin and norepinephrine reuptake inhibitors (SNRIs) are one of the antidepressant drugs prescribed for depression treatment. There are many contradiction studies about the adverse effect and genotoxicity of SNRIs. So here, based on the guidelines proposed at the PRISMA statement, we performed a quantitative systematic review by searching international electronic databases (PubMed, Scopus, Embase, and Web of Science) for published documents on SSNRIs and their genotoxicity effects. The database searches retrieved 336 records, 18 of which met the inclusion criteria. Evaluation of the selected articles showed that a total of 9 articles were appropriate for final review. Most of these studies (78%) reported positive results for the genotoxicity of SNRIs CONCLUSION: Finally, we can conclude that these drugs have the potential to damage DNA.

References

Oct 1, 1992·Free Radical Biology & Medicine·A BindoliD J Deeble
Mar 29, 2000·Environmental and Molecular Mutagenesis·R R TiceY F Sasaki
Jul 20, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Patrícia PereiraPatrícia Ardenghi
Sep 2, 2005·Mutagenesis·G J S JenkinsJ M Parry
Oct 4, 2005·Clinical Therapeutics·Melanie E HunzikerM Lynn Crismon
Dec 13, 2006·Mutation Research·Giovanni Brambilla, Antonietta Martelli
Dec 13, 2006·Mutation Research·David M Wilson, Larry H Thompson
Jul 7, 2007·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·Sanjay GuptaPrakash Masand
Nov 1, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Patrícia PereiraJaqueline Nascimento Picada
May 5, 2009·Toxicology·Giovanni BrambillaAntonietta Martelli
Sep 8, 2010·Environmental Toxicology and Chemistry·Chris D MetcalfeDavid M Andrews
Aug 13, 2011·Pharmacology, Biochemistry, and Behavior·Basel A Abdel-Wahab, Ragaa H Salama
Dec 8, 2011·Methods in Molecular Biology·Raluca A MateucaMicheline Kirsch-Volders
Aug 27, 2013·Critical Reviews in Oncology/hematology·Stéphane PuyoPhilippe Pourquier
Aug 4, 2015·Biological & Pharmaceutical Bulletin·Eduardo Madrigal-BujaidarJosé A Morales-González
Jun 12, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ana Marta SilvaTeresa Cunha-Oliveira
Jul 22, 2018·Drug and Chemical Toxicology·Selim Ayabaktı, Ayşe Yavuz Kocaman
Sep 27, 2019·Journal of Psychopharmacology·Mahnaz AhmadimaneshLeila Etemad

❮ Previous
Next ❯

Citations

Nov 23, 2020·The Science of the Total Environment·Carlos Castillo-ZacaríasRoberto Parra-Saldívar

❮ Previous
Next ❯

Methods Mentioned

BETA
Chromosomal aberrations

Software Mentioned

EndNote

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.