A Systematic Review on the Use of Sacubitril/Valsartan Initiated Prior to Discharge in Hospitalized Patients With Heart Failure.

The Annals of Pharmacotherapy
Krisy-Ann Thornby, Nicole M Maksutovic

Abstract

Systematically review the evidence of sacubitril/valsartan initiated in the hospital setting prior to discharge in patients with acute decompensated heart failure (HF). A literature search using keywords related to sacubitril/valsartan, HF, and inpatient use was performed using MEDLINE, CINAHL, and Google Scholar from inception through May 8, 2020. Eligible studies included patients initiated on sacubitril/valsartan while inpatient and reported efficacy and safety outcomes. A total of 10 articles were included for study review, of which 9 were full text and 1 was a conference poster. Key outcomes of interest were related to tolerability, N-terminal proB-type natriuretic peptide (NT-proBNP), functional capacity, target dose attainment, or rehospitalization rates. NT-proBNP levels were improved in 4 trials, and the results of functional capacity were mixed based on 2 studies. Rehospitalization rates were reported as secondary outcomes, and only 1 large study showed numerical and statistical improvement. The most frequent dose initiated prior to discharge was sacubitril/valsartan 24/26 mg twice daily. Hypotension was the most commonly reported adverse drug reaction and was commonly cited as a reason for not tolerating inpatient in...Continue Reading

References

Nov 3, 2004·The American Journal of Cardiology·Gregg C FonarowWilliam T Abraham
May 16, 2006·Heart·Michael Weber, Christian Hamm
Jun 13, 2009·Journal of the American College of Cardiology·Larry A AllenG Michael Felker
Aug 31, 2013·Circulation Research·Véronique L Roger
Sep 2, 2014·The New England Journal of Medicine·John J V McMurrayUNKNOWN PARADIGM-HF Investigators and Committees
Mar 20, 2016·Journal of Clinical Pharmacy and Therapeutics·A J AnsaraJ M Koehler
Aug 9, 2017·Cardiac Failure Review·Gianluigi Savarese, Lars H Lund
Dec 1, 2017·Journal of the American Heart Association·Emmanuel AkintoyeJarrett Weinberger
Nov 13, 2018·The New England Journal of Medicine·Eric J VelazquezUNKNOWN PIONEER-HF Investigators
Nov 30, 2018·Nature Reviews. Cardiology·Alexandra Le Bras
Feb 7, 2019·The New England Journal of Medicine·John Jarcho
Oct 5, 2019·Journal of Pharmacy Practice·Caitlin C Akerman, Janna C Beavers
Nov 2, 2019·Journal of the American College of Cardiology·Trejeeve MartynRandall C Starling
Nov 9, 2019·ESC Heart Failure·Juan Carlos López-AzorManuel Martínez-Sellés
Jan 30, 2020·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Mar 5, 2020·Journal of Community Hospital Internal Medicine Perspectives·Katie L PeppinMartin W Schwarze

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