A Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity.

Toxicological Sciences : an Official Journal of the Society of Toxicology
Sebastian HoffmannKatya Tsaioun

Abstract

Originally developed to inform the acute toxicity of chemicals on fish, the zebrafish embryotoxicity test (ZET) has also been proposed for assessing the prenatal developmental toxicity of chemicals, potentially replacing mammalian studies. Although extensively evaluated in primary studies, a comprehensive review summarizing the available evidence for the ZET's capacity is lacking. Therefore, we conducted a systematic review of how well the presence or absence of exposure-related findings in the ZET predicts prenatal development toxicity in studies with rats and rabbits. A two-tiered systematic review of the developmental toxicity literature was performed, a review of the ZET literature was followed by one of the mammalian literature. Data were extracted using DistillerSR, and study validity was assessed with an amended SYRCLE's risk-of-bias tool. Extracted data were analyzed for each species and substance, which provided the basis for comparing the 2 test methods. Although limited by the number of 24 included chemicals, our results suggest that the ZET has potential to identify chemicals that are mammalian prenatal developmental toxicants, with a tendency for overprediction. Furthermore, our analysis confirmed the need for furt...Continue Reading

References

Dec 1, 1986·Teratology·J A PetrereF A de la Iglesia
Jan 1, 1988·Journal of Toxicology and Environmental Health·R InfurnaJ Barnett
Sep 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T F CollinsM W O'Donnell
Jul 1, 1982·Journal of Toxicology and Environmental Health·K S KheraG Angers
Mar 1, 1983·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·L L OngF A de la Iglesia
Oct 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·T R HanleyB A Schwetz
Dec 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·G L Kennedy, A M Kaplan
Jan 1, 1983·Drug and Chemical Toxicology·R R MaronpotN J Smith
Dec 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T F CollinsD I Ruggles
Feb 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·W C HayesK S Rao
Mar 1, 1995·Bulletin of Environmental Contamination and Toxicology·K Machera
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Mar 1, 1997·Journal of the American Academy of Dermatology·R E SeegmillerW J Powers
Jun 2, 1998·Development Genes and Evolution·M W VanderseaD G Smith
Nov 24, 1999·Reproductive Toxicology·I ChahoudA S Faqi
Jul 7, 2001·Ecotoxicology and Environmental Safety·C WiegandS Pflugmacher
Jul 30, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·George R LankasL David Wise
Aug 31, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·George P Daston
Aug 11, 2005·Journal of Applied Toxicology : JAT·Bryan Ballantyne, William M Snellings
Aug 26, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Christopher TonCatherine Willett
Apr 17, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R Michael McClainJochen Bausch
Jul 30, 2008·Alternatives to Laboratory Animals : ATLA·Sebastian HoffmannEfstathios Nikolaidis
May 2, 2009·Reproductive Toxicology·Lixin YangUwe Strähle
May 19, 2009·Reproductive Toxicology·Ingrid W T SelderslaghsHilda E Witters
Jun 18, 2009·Journal of Applied Toxicology : JAT·A David, K Pancharatna
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Feb 19, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Kimberly C BrannenKaren A Augustine-Rauch
Jan 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K Herrmann
Jan 18, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sanne A B HermsenAldert H Piersma
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Aug 18, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E TeixidóJ M Llobet
Nov 10, 2012·Methods in Molecular Biology·Bengt R Danielsson
Jan 5, 2013·Environmental Science and Pollution Research International·Joanne PérezSusana Loureiro
Mar 21, 2013·Reproductive Toxicology·A H PiersmaB van der Burg
May 15, 2013·ALTEX·Thomas HartungMartin Stephens

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.