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A systematic survey of an intragenic epistatic landscape

bioRxiv

Oct 23, 2014

Claudia BankDaniel N. A. Bolon

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Abstract

Mutations are the source of evolutionary variation. The interactions of multiple mutations can have important effects on fitness and evolutionary trajectories. We have recently described the distribution of fitness effects of all single mutations for a nine amino acid region of yeast Hs...read more

Mentioned in this Paper

Landscapes
Amino Acid [EPC]
Biophysics
HSP90AA1 wt Allele
Mutant
Positioning Attribute
Mutant Proteins
Mutation Abnormality
Classification
Patterns
11
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  • A systematic survey of an intragenic epistatic landscape

    bioRxiv

    Oct 23, 2014

    Claudia BankDaniel N. A. Bolon

    PMID: 990010645

    DOI: 10.1101/010645

    Abstract

    Mutations are the source of evolutionary variation. The interactions of multiple mutations can have important effects on fitness and evolutionary trajectories. We have recently described the distribution of fitness effects of all single mutations for a nine amino acid region of yeast Hs...read more

    Mentioned in this Paper

    Landscapes
    Amino Acid [EPC]
    Biophysics
    HSP90AA1 wt Allele
    Mutant
    11

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