A systems biology analysis connects insulin receptor signaling with glucose transporter translocation in rat adipocytes.

The Journal of Biological Chemistry
Niclas BergqvistKarin G Stenkula

Abstract

Type 2 diabetes is characterized by insulin resistance, which arises from malfunctions in the intracellular insulin signaling network. Knowledge of the insulin signaling network is fragmented, and because of the complexity of this network, little consensus has emerged for the structure and importance of the different branches of the network. To help overcome this complexity, systems biology mathematical models have been generated for predicting both the activation of the insulin receptor (IR) and the redistribution of glucose transporter 4 (GLUT4) to the plasma membrane. Although the insulin signal transduction between IR and GLUT4 has been thoroughly studied with modeling and time-resolved data in human cells, comparable analyses in cells from commonly used model organisms such as rats and mice are lacking. Here, we combined existing data and models for rat adipocytes with new data collected for the signaling network between IR and GLUT4 to create a model also for their interconnections. To describe all data (>140 data points), the model needed three distinct pathways from IR to GLUT4: (i) via protein kinase B (PKB) and Akt substrate of 160 kDa (AS160), (ii) via an AS160-independent pathway from PKB, and (iii) via an additiona...Continue Reading

References

May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·K Suzuki, T Kono
Jun 11, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·H HaunerJ Eckel
Oct 30, 2001·The Proceedings of the Nutrition Society·K N Frayn
Feb 13, 2003·Science's STKE : Signal Transduction Knowledge Environment·Anders TengholmTobias Meyer
Mar 15, 2003·The Journal of Biological Chemistry·Hiroyuki SanoGustav E Lienhard
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sudhir B KondapakaSamuel W Cushman
Feb 19, 2005·Science·D D SarbassovDavid M Sabatini
Sep 13, 2005·Cell Metabolism·Françoise KoumanovGeoffrey D Holman
Oct 11, 2005·Cell Metabolism·Lorena EguezTimothy E McGraw
Mar 11, 2008·Archives of Biochemistry and Biophysics·J BurénJ Jensen
Jan 24, 2009·Science·Thomas C Südhof, James E Rothman
Feb 20, 2009·Molecular Systems Biology·Vladislav V KiselyovPierre De Meyts
Mar 3, 2009·Vitamins and Hormones·Joseph M Muretta, Cynthia Corley Mastick
Jan 14, 2011·Traffic·Nia J Bryant, Gwyn W Gould
Mar 30, 2011·The Journal of Cell Biology·Jenna L JewellDebbie C Thurmond
May 27, 2011·The Journal of Biological Chemistry·Paul Duffield BrewerCynthia Corley Mastick
Mar 23, 2013·PloS One·Vladimir A LizunovJoshua Zimmerberg
Mar 25, 2014·Diabetes & Metabolism·R Govers
Apr 30, 2014·The Journal of Biological Chemistry·Paul Duffield BrewerAdelle C F Coster
May 20, 2014·Nature Communications·Nikhil R Gandasi, Sebastian Barg

❮ Previous
Next ❯

Citations

Oct 30, 2019·International Journal of Molecular Sciences·Yang ChenChen Chen
Jul 28, 2021·Biomedical Physics & Engineering Express·Darshna M JoshiHardik Bhatt

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Related Papers

Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University
Hui-xia LiuBi-lian Chen
Hormone Molecular Biology and Clinical Investigation
Atul S Deshmukh
Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Gregory D Cartee, Jørgen F P Wojtaszewski
© 2022 Meta ULC. All rights reserved