A systems biology approach to the mutual interaction between yeast and the immune system

Immunobiology
Lisa Rizzetto, Duccio Cavalieri

Abstract

Dendritic cells (DCs) are capable of sensing fungi and then to initiate an appropriate defense against the invading microbe. We studied interactions between host and microorganism by analyzing the transcriptional response of DCs stimulated by the harmless Saccharomyces cerevisiae and of this phagocytosed fungus. Pathway analyses provided insight into the mutual interactions. Of particular interest was the responses elicited by the DC in the fungus, including downregulation of the carbon-compound metabolism, and upregulation of lipid, fatty acid, glyoxylate and tricarboxylic acid cycles. This indicates that the yeast shifts to a starvation mode and induces morphogenetic and autophagic pathways as well as those associated with reshaping cell wall composition, to resist the immune clearance. This yeast response is independent of the presence of virulence traits as the same transcriptional cell reprogramming has also been observed in potentially pathogenic C. albicans hyphae phagocytosed by macrophages. When comparing our results with the previous findings, it appears that the yeast dimorphic switch is only one of the components of the evolutionarily conserved panels of survival strategies elicited by phagocytosis. In conclusion, a...Continue Reading

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Citations

Mar 12, 2011·Nature Reviews. Immunology·Luigina Romani
Nov 22, 2011·PLoS Pathogens·Thierry FontaineJean-Paul Latgé
Sep 6, 2011·Immunobiology·Rodrigo SantamaríaMisha Kapushesky
Aug 30, 2011·Trends in Microbiology·Lisa Rizzetto, Duccio Cavalieri
Nov 13, 2010·Drug Discovery Today. Disease Mechanisms·Helena I M Boshoff, Desmond S Lun
Sep 8, 2010·Current Opinion in Biotechnology·Vítor Martins dos SantosWillem M de Vos
Jun 22, 2012·Current Opinion in Microbiology·Lanay TierneyDuccio Cavalieri

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