A systems pharmacology approach to investigate the mechanism of Oryeong-san formula for the treatment of hypertension

Journal of Ethnopharmacology
Sang-Kyun KimSanghun Lee

Abstract

Oryeong-san (ORS) is a traditional formula that has long been used for the treatment of dysfunctions of body fluids and electrolyte homeostasis in Korea, China and Japan. Recent reports have shown that ORS may suppress hypertension by controlling the renin-angiotensin-aldosterone system (RAAS) in the kidney, but its action mechanism has not been well defined. The aim of this study was to decipher the ORS mechanisms in the treatment of hypertension using a systems pharmacology approach. The compounds of ORS were obtained from the TM-MC (database of medicinal materials and chemical compounds in Northeast Asian traditional medicine), and the drug-likeness (DL) and oral bioavailability (OB) of the compounds were evaluated. The potential targets of the compounds were identified using various pharmacology databases. To analyze the mechanisms of the ORS for hypertension, a Compound-Target-Disease (C-T-D) network was established with respect to the genes related to hypertension. A screening evaluation of the DL and OB of the ORS compounds identified a list of 232 active compounds. The pharmacological activity of the targets was investigated by exploring the interaction network between the compounds and the targets. Analysis of the inte...Continue Reading

Citations

Sep 4, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·VinayKumar DachuriChang-Hyun Song
Feb 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Qionglong JinLichang Wang
May 1, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yunsen ZhangYi Zhang

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