A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation

Journal of Autoimmunity
Ana C AndersonVijay K Kuchroo

Abstract

Genetic variants in il2 and il2ra have been associated with autoimmune disease susceptibility in both genome-wide association studies (GWAS) in humans and in genetic linkage studies in experimental models of autoimmunity. Specifically, genetic variants resulting in a low IL-2 phenotype are susceptibility alleles while variants resulting in a high IL-2 phenotype are resistance alleles. The association of high IL-2 phenotypes with resistance has been attributed primarily to the T cell intrinsic promotion of regulatory T cell development, maintenance, and function; however, IL-2 can also act T cell intrinsically to dampen differentiation of pathogenic IL-17-producing Th17 cells. Here, we have uncovered a novel T cell extrinsic mechanism whereby IL-2 promotes both IFN-γ and IL-27 production from tissue resident macrophages which in turn dampen the differentiation of pathogenic Th17 cells.

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Citations

Mar 31, 2016·Clinical Reviews in Allergy & Immunology·Yaxiong DengQianjin Lu
Aug 13, 2015·Clinical Reviews in Allergy & Immunology·Yu-Qing XieZhe-Xiong Lian
Mar 17, 2017·Clinical Reviews in Allergy & Immunology·Andrea T BorchersM Eric Gershwin
Oct 16, 2016·Journal of Immunotherapy·Maggie L DillerMandy L Ford
Nov 12, 2015·Frontiers in Immunology·Prenitha Mercy Ignatius Arokia DossManu Rangachari
Apr 3, 2021·American Journal of Human Genetics·Minal CaliskanJoseph C Maranville

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

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