A t(12;17) in an extraorbital giant cell angiofibroma

Cancer Genetics and Cytogenetics
You-Wen QianMeera Hameed

Abstract

We report a case of a 43-year-old male who presented with a large soft-tissue neck mass 7 years ago. A diagnosis of giant cell angiofibroma (GCA) was made on the basis of light microscopy and immunohistochemical studies. Chromosome analysis showed a male karyotype with t(12;17)(q15;q23),del(18)(q21) in all 20 cells analyzed. This cytogenetic abnormality in GCA is different from the t(17;22)(q22;q13) found in related lesions, such as giant cell fibroblastoma and solitary fibrous tumor, none of which has a specific chromosomal abnormality. Our case is the second case of GCA with chromosomal aberrations. To the best of our knowledge, this is the first case of GCA with t(12;17) occurring as an extra-orbital mass.

References

Feb 25, 1998·Biochemical and Biophysical Research Communications·N TanahashiK Tanaka
Jan 5, 2000·Cancer Genetics and Cytogenetics·H SonobeY Ohtsuki
Jun 5, 2001·Ophthalmic Plastic and Reconstructive Surgery·B YaziciB J McKenna
Dec 6, 2001·Cancer Genetics and Cytogenetics·M Debiec-RychterR Sciot

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Citations

Aug 31, 2012·Case Reports in Pathology·Emel Ebru PalaUlku Kucuk
Nov 16, 2013·Surgical Neurology International·Muhammad Z ArifinBethy S Hernowo
Oct 21, 2009·Orbit·Jwu Jin KhongDinesh Selva

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