PMID: 6983692Nov 1, 1982Paper

A T15-idiotype-positive T suppressor hybridoma does not use the T15 VH gene segment

Proceedings of the National Academy of Sciences of the United States of America
K NakanishiT Kishimoto

Abstract

The T suppressive factor (TsF) released from a T15-idiotype-positive phosphocholine (PCho)-specific T hybridoma, F18-3-4, which was formed by fusion between BALB/c T cells and BW5147 thymoma, was immunochemically characterized. TsF inhibited the in vitro induction of both IgE and IgG1 antibody responses of 2,4-dinitrophenyl keyhole limpet hemocyanin (DNP-KLH)-primed spleen cells in the presence of PCho-KLH-DNP. TsF had the ability to bind to PCho determinants and possessed T15 idiotype determinants as well as Iad products. However, we were unable to detect either the rearrangement of the T15 VH gene or the presence of T15 VH gene transcripts in hybridomas by DNA and RNA blot hybridization analyses with the T15 VH DNA probe.

References

Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas
Jan 1, 1982·The Journal of Experimental Medicine·G G MillerD H Sachs
Dec 1, 1980·The Journal of Experimental Medicine·M KronenbergJ D Watson

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Citations

Sep 1, 1987·Molecular Immunology·N YamasakiT Watanabe
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P P ChenD A Carson
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S M HedrickY Kaufmann
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K T HayGlassM S Sy
Jul 1, 1983·The Journal of Experimental Medicine·M KronenbergL Hood
Sep 1, 1984·The Journal of Experimental Medicine·N E LeeM M Davis
May 1, 1983·Immunology Today·J F MillerI D Walker
Aug 1, 1988·International Reviews of Immunology·M E DorfR M O'Hara
Dec 8, 1983·Nature·A Munro
Jan 1, 1988·Immunological Reviews·M S Sy, B Benacerraf
Oct 1, 1984·Immunological Reviews·M M DavisS M Hedrick
Nov 1, 2007·European Journal of Immunology·Tak W Mak

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