A tale of three genomes: the kinetoplastids have arrived

Trends in Parasitology
Jessica C Kissinger

Abstract

July 2005 marked a milestone in kinetoplastid biology research. A tour de force effort led by the Tri-Trypanosomatidae "Tritryp" genome consortium yielded the publication of three prominent kinetoplastid parasite genome sequences: Trypanosoma brucei, Trypanosoma cruzi and Leishmania major. The individual and combined comparative analyses of these three genome sequences, combined with proteomic analyses, have yielded insights into topics ranging from genome evolution and horizontal gene transfer to potential new therapeutic and vaccine targets.

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Citations

Nov 15, 2006·BMC Molecular Biology·Hubert DeniseJeremy C Mottram
Jan 27, 2009·Infection and Immunity·Nicolas Antoine-MoussiauxDaniel Desmecht
Apr 21, 2009·Journal of Proteome Research·Esteban M CorderoJosé Franco da Silveira
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Dec 14, 2017·Expert Opinion on Drug Discovery·Eric Chatelain, Jean-Robert Ioset
Jun 19, 2018·Frontiers in Microbiology·Luis M de Pablos TorróAntonio Osuna
May 1, 2018·Microbial Genomics·Luisa BernáCarlos Robello

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