Apr 14, 2020

Ahr-bacterial diet interaction modulates aging and associated pathologies in C. elegans

BioRxiv : the Preprint Server for Biology
V. BrinkmannNatascia Ventura


Genetic and environmental factors concurrently shape the aging process. The nematode Caenorhabditis elegans has been instrumental in the past 30 years to identify most factors and pathways nowadays known to modulate aging. The aryl-hydrocarbon-receptor (AhR) is a transcription factor originally discovered as a dioxin-binding protein and involved in the metabolism of different environmental toxicants and xenobiotics. Since its discovery, the variety of pathophysiological processes regulated by the AhR has grown and previously we disclosed it promotes aging phenotypes across species. Here, we followed up on our previous study and show that lack of C. elegans AHR-1 differentially affects health and lifespan in a context-dependent manner. Notably, we identified a critical role for AhR-bacterial diet interaction in animal lifespan, stress resistance, and age-associated pathologies, and narrowed down the dietary factor involved in the observed AhR-dependent features to a bacteria extruded product, likely derived from tryptophan metabolism.

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Mentioned in this Paper

Research Personnel
Nucleic Acid Sequencing
Phylogenetic Analysis
High Throughput Analysis
Oligonucleotide Primers
Saline Solution, Hypertonic

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