A task-invariant cognitive reserve network

NeuroImage
Yaakov SternChristian Habeck

Abstract

The concept of cognitive reserve (CR) can explain individual differences in susceptibility to cognitive or functional impairment in the presence of age or disease-related brain changes. Epidemiologic evidence indicates that CR helps maintain performance in the face of pathology across multiple cognitive domains. We therefore tried to identify a single, "task-invariant" CR network that is active during the performance of many disparate tasks. In imaging data acquired from 255 individuals age 20-80 while performing 12 different cognitive tasks, we used an iterative approach to derive a multivariate network that was expressed during the performance of all tasks, and whose degree of expression correlated with IQ, a proxy for CR. When applied to held out data or forward applied to fMRI data from an entirely different activation task, network expression correlated with IQ. Expression of the CR pattern accounted for additional variance in fluid reasoning performance over and above the influence of cortical thickness, and also moderated between cortical thickness and reasoning performance, consistent with the behavior of a CR network. The identification of a task-invariant CR network supports the idea that life experiences may result i...Continue Reading

Citations

Mar 10, 2019·Brain : a Journal of Neurology·Eider M Arenaza-UrquijoPrashanthi Vemuri
Oct 12, 2019·Social Cognitive and Affective Neuroscience·Chih-Mao HuangTatia M C Lee
Jan 11, 2019·Current Neurology and Neuroscience Reports·Corinne Pettigrew, Anja Soldan
Feb 25, 2020·Neurorehabilitation and Neural Repair·Emily RosenichSusan L Hillier
Dec 7, 2018·Journal of Alzheimer's Disease : JAD·Arianna MenardiEmiliano Santarnecchi
May 22, 2020·International Psychogeriatrics·Felix S HussenoederFrancisca S Rodriguez
Sep 27, 2019·Frontiers in Aging Neuroscience·Eleanna VarangisYaakov Stern
Aug 29, 2019·Language, Cognition and Neuroscience·Perrine FerréPierre Bellec
Oct 9, 2019·Journal of Alzheimer's Disease : JAD·Emma RichardsAndrea Tales
Jul 9, 2020·Journal of Neurology·Timothy Rittman
Oct 12, 2018·Nature Reviews. Neuroscience·Roberto CabezaM Natasha Rajah
Apr 9, 2019·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Rachel L PetersonScott C Carvajal
Dec 29, 2020·NeuroImage. Clinical·Sylvie BellevilleUNKNOWN CIMA-Q group
Aug 11, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Moataz AssemEvelina Fedorenko
Feb 2, 2021·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Sebastián A Balart-SánchezNatasha M Maurits
Feb 9, 2021·Brain Structure & Function·Lukas LenhartChristoph Scherfler
Apr 19, 2021·Cerebral Cortex·Lissett Gonzalez-BurgosDaniel Ferreira
Mar 17, 2021·Brain : a Journal of Neurology·Michael EwersUNKNOWN Alzheimer’s Disease Neuroimaging Initiative and the Dominantly Inherited Alzheimer Network
Aug 1, 2021·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Adam VujicSharon L Naismith
Sep 28, 2021·Frontiers in Aging Neuroscience·Kristína MitterováIrena Rektorová
Oct 16, 2021·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Yaakov Stern
Aug 30, 2019·Dementia and Geriatric Cognitive Disorders·Francisca S RodriguezUNKNOWN Aging Brain: Vasculature, Ischemia, and Behavior Study
Dec 14, 2021·NeuroImage·Eleanna VarangisSeonjoo Lee

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