PMID: 2305004Jan 1, 1990

A taste aversion model of drug discrimination learning: training drug and condition influence rate of learning, sensitivity and drug specificity

Psychopharmacology
T V Jaeger, R F Mucha

Abstract

A model of drug discrimination based on a lithium chloride (LiCl) flavour aversion was described and examined. Mildly thirsty rats were presented daily with 4 ml of a distinctly flavoured solution which was followed on 50% of the days by an IP injection of LiCl. Prior to the flavour presentation, the rats were injection SC with saline or a training drug (0.04 mg/kg fentanyl or 20 mg/kg pentobarbital) to signal whether LiCl would follow. Almost all rats eventually exhibited stable behaviour that involved drinking most or all of the fluid when it was not to be followed by LiCl and little or no drinking when it was. Such discrimination occurred regardless of whether drug predicted LiCl (learned-discomfort) or predicted no LiCl (learned-safety). However, with fentanyl there were clear differences between rats trained with drug under learned-safety and under learned-discomfort conditions for 1) the rate of acquisition of stable performance as a function of LiCl dose, 2) generalization of the training dose to a test dose that was lower, and 3) elicitation of fentanyl responses by pentobarbital. These findings, together with indications that such effects did not always occur with pentobarbital as the training drug, were discussed from...Continue Reading

References

Dec 1, 1978·Pharmacology, Biochemistry, and Behavior·F C Colpaert
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·J P MastropaoloAnthony L Riley
Oct 1, 1970·Journal of Comparative and Physiological Psychology·M Nachman
Jan 1, 1982·Progress in Neurobiology·J A Richter, J R Holtman
Apr 1, 1982·Journal of Comparative and Physiological Psychology·S RevuskyR W Pohl

Citations

Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·S T SmurthwaiteAnthony L Riley
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·G W StevensonAnthony L Riley
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·A Van HestB Olivier
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·S T Smurthwaite, Anthony L Riley
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·S Pournaghash, Anthony L Riley
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·S T Smurthwaite, Anthony L Riley
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·I LuckiD S Kreiss
Nov 1, 1992·Behavioral and Neural Biology·D M Skinner, G M Martin
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·T U Järbe, R J Lamb
Dec 14, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew I PalmatierRick A Bevins
May 5, 2007·Pharmacology, Biochemistry, and Behavior·Jennifer E MurrayRick A Bevins
May 15, 2015·Pharmacology, Biochemistry, and Behavior·Jonathan K Gore-LangtonAnthony L Riley
Sep 1, 1992·British Journal of Addiction·P Campion, M Farrell
Jul 1, 1991·British Journal of Addiction·S Cranfield, A Dixon

Related Concepts

Metazoa
Avoidance Learning
Discrimination Learning
Dose-Response Relationship, Drug
Drug Interactions
Sublimaze
Lithium
Diabutal
August Rats
Taste Perception

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