PMID: 2305004Jan 1, 1990

A taste aversion model of drug discrimination learning: training drug and condition influence rate of learning, sensitivity and drug specificity

T V Jaeger, R F Mucha


A model of drug discrimination based on a lithium chloride (LiCl) flavour aversion was described and examined. Mildly thirsty rats were presented daily with 4 ml of a distinctly flavoured solution which was followed on 50% of the days by an IP injection of LiCl. Prior to the flavour presentation, the rats were injection SC with saline or a training drug (0.04 mg/kg fentanyl or 20 mg/kg pentobarbital) to signal whether LiCl would follow. Almost all rats eventually exhibited stable behaviour that involved drinking most or all of the fluid when it was not to be followed by LiCl and little or no drinking when it was. Such discrimination occurred regardless of whether drug predicted LiCl (learned-discomfort) or predicted no LiCl (learned-safety). However, with fentanyl there were clear differences between rats trained with drug under learned-safety and under learned-discomfort conditions for 1) the rate of acquisition of stable performance as a function of LiCl dose, 2) generalization of the training dose to a test dose that was lower, and 3) elicitation of fentanyl responses by pentobarbital. These findings, together with indications that such effects did not always occur with pentobarbital as the training drug, were discussed from...Continue Reading


Dec 1, 1978·Pharmacology, Biochemistry, and Behavior·F C Colpaert
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·J P MastropaoloAnthony L Riley
Oct 1, 1970·Journal of Comparative and Physiological Psychology·M Nachman
Jan 1, 1982·Progress in Neurobiology·J A Richter, J R Holtman
Apr 1, 1982·Journal of Comparative and Physiological Psychology·S RevuskyR W Pohl


Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·S T SmurthwaiteAnthony L Riley
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·G W StevensonAnthony L Riley
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·A Van HestB Olivier
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·S T Smurthwaite, Anthony L Riley
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·S Pournaghash, Anthony L Riley
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·S T Smurthwaite, Anthony L Riley
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·I LuckiD S Kreiss
Nov 1, 1992·Behavioral and Neural Biology·D M Skinner, G M Martin
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·T U Järbe, R J Lamb
Dec 14, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew I PalmatierRick A Bevins
May 5, 2007·Pharmacology, Biochemistry, and Behavior·Jennifer E MurrayRick A Bevins
May 15, 2015·Pharmacology, Biochemistry, and Behavior·Jonathan K Gore-LangtonAnthony L Riley
Sep 1, 1992·British Journal of Addiction·P Campion, M Farrell
Jul 1, 1991·British Journal of Addiction·S Cranfield, A Dixon

Related Concepts

Avoidance Learning
Discrimination Learning
Dose-Response Relationship, Drug
Drug Interactions
August Rats
Taste Perception

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.