A taxonomy of seizure dynamotypes.

ELife
Maria Luisa SaggioWilliam C Stacey

Abstract

Seizures are a disruption of normal brain activity present across a vast range of species and conditions. We introduce an organizing principle that leads to the first objective Taxonomy of Seizure Dynamics (TSD) based on bifurcation theory. The 'dynamotype' of a seizure is the dynamic composition that defines its observable characteristics, including how it starts, evolves and ends. Analyzing over 2000 focal-onset seizures from multiple centers, we find evidence of all 16 dynamotypes predicted in TSD. We demonstrate that patients' dynamotypes evolve during their lifetime and display complex but systematic variations including hierarchy (certain types are more common), non-bijectivity (a patient may display multiple types) and pairing preference (multiple types may occur during one seizure). TSD provides a way to stratify patients in complement to present clinical classifications, a language to describe the most critical features of seizure dynamics, and a framework to guide future research focused on dynamical properties.

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Citations

Sep 19, 2020·Epilepsia·Jared M ScottWilliam C Stacey
May 15, 2021·Epilepsy Currents·Kathryn A DavisCatherine A Schevon
Jun 12, 2021·NeuroImage·Amirhossein JafarianKarl J Friston
Jul 6, 2021·Seizure : the Journal of the British Epilepsy Association·Damien DepannemaeckerChristophe Bernard
Aug 11, 2021·NeuroImage. Clinical·Farrokh ManzouriAndreas Schulze-Bonhage
Nov 3, 2021·Communications Biology·Anirudh N VattikondaViktor K Jirsa

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Software Mentioned

Epileptor
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