PMID: 9541577Apr 29, 1998Paper

A TCR alpha chain transgene induces maturation of CD4- CD8- alpha beta+ T cells from gamma delta T cell precursors

European Journal of Immunology
M FritschF Ivars

Abstract

The proportion of CD4- CD8- double-negative (DN) alpha beta T cells is increased both in the thymus and in peripheral lymphoid organs of TCR alpha chain-transgenic mice. In this report we have characterized this T cell population to elucidate its relationship to alpha beta and gamma delta T cells. We show that the transgenic DN cells are phenotypically similar to gamma delta T cells but distinct from DN NK T cells. The precursors of DN cells have neither rearranged endogenous TCR alpha genes nor been negatively selected by the MIsa antigen, suggesting that they originate from a differentiation stage before the onset of TCR alpha chain rearrangements and CD4/CD8 gene expression. Neither in-frame V delta D delta J delta nor V gamma J gamma rearrangements are over-represented in this population. However, since peripheral gamma delta T cells with functional TCR beta gene rearrangements have been depleted in the transgenics, we propose that the transgenic DN population, at least partially, originates from the precursors of those cells. The present data lend support to the view that maturation signals to gamma delta lineage-committed precursors can be delivered via TCR alpha beta heterodimers.

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Citations

Mar 3, 2001·Current Opinion in Immunology·H R MacDonaldA Wilson
May 14, 1999·Current Opinion in Immunology·H von BoehmerO Azogui
Sep 10, 2009·The Journal of Experimental Medicine·Monica W L LeungJuan J Lafaille
Jun 19, 2002·The Journal of Experimental Medicine·Maddalena PanigadaFabio Grassi
Mar 3, 2004·The Journal of Experimental Medicine·Christine BorowskiHarald von Boehmer
Jul 7, 2005·The Journal of Experimental Medicine·Troy A BaldwinKristin A Hogquist
Mar 11, 2005·Journal of Theoretical Biology·Nuno SepúlvedaJorge Carneiro
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May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul GaduePaul L Stein
Jan 13, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pablo PereiraAna Cumano
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·David GerberPablo Pereira
Mar 5, 2003·Immunological Reviews·Harald von BoehmerLudger Klein
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M SköldS Cardell
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K Petersson, F Ivars
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Aug 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roxanne CollinSylvie Lesage

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