A technique for continuous bedside monitoring of global cerebral energy state

Intensive Care Medicine Experimental
Rasmus JakobsenCarl-Henrik Nordström

Abstract

Cerebral cytoplasmatic redox state is a sensitive indicator of cerebral oxidative metabolism and is conventionally evaluated from the extracellular lactate/pyruvate (LP) ratio. In the present experimental study of global cerebral ischemia induced by hemorrhagic shock, we investigate whether the LP ratio obtained from microdialysis of cerebral venous blood may be used as a surrogate marker of global cerebral energy state. Six female pigs were anesthetized and vital parameters were recorded. Microdialysis catheters were placed in the left parietal lobe, the superior sagittal sinus, and the femoral artery. Hemorrhagic shock was achieved by bleeding the animals to a mean arterial pressure (MAP) of approximately 40 mmHg and kept at a MAP of about 30-40 mmHg for 90 min. The animals were resuscitated with autologous whole blood followed by 3 h of observation. The LP ratio obtained from the intracerebral and intravenous catheters immediately increased during the period of hemorrhagic shock while the LP ratio in the arterial blood remained close to normal levels. At the end of the experiment, median LP ratio (interquartile range) obtained from the intracerebral, intravenous, and intra-arterial microdialysis catheters were 846 (243-1990)...Continue Reading

References

Oct 1, 1991·Journal of Internal Medicine·U Ungerstedt
Apr 1, 1993·The American Journal of Physiology·R C Poole, A P Halestrap
May 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·L HilleredL Persson
Sep 5, 2002·Nature Reviews. Neuroscience·Maiken NedergaardAnker J Hansen
Jul 29, 2003·Journal of Pharmaceutical Sciences·Bradley E Enerson, Lester R Drewes
Nov 19, 2004·Intensive Care Medicine·Bo-Michael BellanderNiels Vidiendal Olsen
Feb 18, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Paul VespaDavid A Hovda
Mar 31, 2005·Journal of Neurosurgery·Martin EngströmCarl-Henrik Nordström
Jun 15, 2005·Journal of Neurochemistry·Karin Pierre, Luc Pellerin
Jan 18, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carolina SamuelssonElisabeth Ronne-Engström
Feb 6, 2008·Neurocritical Care·Peter Nissen BjerringFin Stolze Larsen
Apr 22, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Silvana F MarascoMichael J Abramson
Jan 23, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Pascale LavoieOlivier Levrier
Feb 27, 2009·Acta Anaesthesiologica Scandinavica·J NordmarkP Enblad
Nov 26, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Carl-Henrik Nordström
Jan 14, 2010·Critical Care Medicine·Zhi WanWanchun Tang
Jan 16, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Isis Amer-WåhlinCarl Henrik Nordström
Feb 20, 2010·Critical Care Medicine·Fabio Silvio Taccone, Daniel De Backer
Oct 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fawzi BoumezbeurDouglas L Rothman
Dec 14, 2011·IUBMB Life·Andrew P Halestrap, Marieangela C Wilson
Dec 22, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gerald A Dienel
Jan 20, 2012·The New England Journal of Medicine·Ola A SelnesGuy M McKhann
Jan 17, 2013·Critical Care : the Official Journal of the Critical Care Forum·Nino StocchettiJean-Louis Vincent
Mar 19, 2013·Acta Anaesthesiologica Scandinavica·T H NielsenC H Nordström
Aug 29, 2013·Journal of Anesthesia·Tomoko Goto, Kengo Maekawa
Apr 2, 2014·Critical Care : the Official Journal of the Critical Care Forum·Fanny SchierenbeckJan Liska
May 7, 2014·Acta Neurologica Scandinavica·A JacobsenC H Nordström
Jul 2, 2014·The Neurohospitalist·Elizabeth A CahillSandeep Khot
Sep 11, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gerald A Dienel

❮ Previous
Next ❯

Citations

Jul 5, 2017·Frontiers in Neurology·Carl-Henrik NordströmMagnus Olivecrona
Feb 15, 2021·Resuscitation·Carl-Henrik NordströmTroels Halfeld Nielsen

❮ Previous
Next ❯

Methods Mentioned

BETA
urine collection

Software Mentioned

Stata

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.