PMID: 9271019Aug 1, 1997

A technique for obtaining repeated liver biopsies from rats

P L CmielewskiP M Hall


Many morphological, pharmacological and toxicological studies of hepatotoxicity require frequent sampling of liver over time. In the past this has been achieved by including large numbers of animals in the study and killing subgroups at different times. In this paper we describe a technique for repeated liver biopsy that procures sufficient liver tissue for histopathological assessment and for additional studies, for example measurement of hepatic iron concentration or vitamin A measurement. The advantages and disadvantages of this technique are discussed.


Mar 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J OlynykP D Hall
May 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P D HallM J Cousins
May 1, 1986·British Journal of Anaesthesia·J L PlummerM J Cousins
Dec 1, 1994·Alcoholism, Clinical and Experimental Research·J L PlummerR A Williams


Jul 28, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jason R ClapperJonathan D Roth
Jun 15, 2019·Acta Veterinaria Scandinavica·Kamila Glińska-SuchockaDominika Kubiak-Nowak

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