A technique for rapid exchange of continuous renal replacement therapy

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Peter YorginSteve Alexander

Abstract

Re-initiation of continuous renal replacement therapy (CRRT) in neonates and young infants weighing less than 15 kg often necessitates a blood prime of the blood circuit path or a concurrent packed red blood cell (PRBC) transfusion to avoid causing hemodynamic instability due to acute hemodilution. The significant amount of time required for a routine CRRT circuit change can be associated with worsening electrolyte and acid-base abnormalities, fluid retention, greater hemodynamic instability and reducing effective hemofiltration time. In an attempt to limit the time without CRRT and to eliminate the requirement for additional blood exposure, a new technique, rapid exchange of continuous renal replacement therapy (RECRRT), was developed. Rapid exchange of continuous renal replacement therapy is a sequential technique that transfers citrated blood from one CRRT machine to another machine connected in series. The technique effectively negates the requirement for CRRT circuit path blood priming or PRBC transfusion. The amount of time without CRRT is markedly reduced by RECRRT to 2-3 min. The RECRRT technique has been utilized more than 30 times for at least 15 patients without an adverse event. RECRRT may benefit children who weigh...Continue Reading

References

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Aug 28, 2003·Artificial Organs·Stuart L Goldstein

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Citations

Dec 3, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Fabio PaglialongaAlberto Edefonti
Jan 14, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Navyn NaranKevin R Bock
Mar 6, 2012·The International Journal of Artificial Organs·Farah N Ali, Jerome C Lane

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