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A Temporal Quantitative Profiling of Newly Synthesized Proteins during Aβ Accumulation

bioRxiv

Jan 15, 2020

Yuanhui MaJohn R. Yates

Abstract

Accumulation of aggregated amyloid beta (Aβ) in the brain is believed to impair multiple cellular pathways and play a central role in Alzheimer's disease pathology. But how this process is regulated remains unclear. In theory, measuring protein synthesis is the most direct way to evalua...read more

Mentioned in this Paper

PSEN1
DNA Fingerprinting
Pathogenesis
Patterns
Coat Protein Complex I
Signal Pathways
Isotope Labeling
Hippocampus (Brain)
PALM
Alzheimer Disease, Early Onset
1
Paper Details
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© 2020 Meta ULC. All rights reserved

A Temporal Quantitative Profiling of Newly Synthesized Proteins during Aβ Accumulation

bioRxiv

Jan 15, 2020

Yuanhui MaJohn R. Yates

DOI: 10.1101/2020.01.14.906560

Abstract

Accumulation of aggregated amyloid beta (Aβ) in the brain is believed to impair multiple cellular pathways and play a central role in Alzheimer's disease pathology. But how this process is regulated remains unclear. In theory, measuring protein synthesis is the most direct way to evalua...read more

Mentioned in this Paper

PSEN1
DNA Fingerprinting
Pathogenesis
Patterns
Coat Protein Complex I
Signal Pathways
Isotope Labeling
Hippocampus (Brain)
PALM
Alzheimer Disease, Early Onset
1

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Paper Details
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