PMID: 602761Jan 1, 1977Paper

A teratological evaluation of anticonvulsant drugs

Acta Paediatrica Academiae Scientiarum Hungaricae
P Lakos, E Czeizel

Abstract

Reviewing the important teratological data on anticonvulsants, the Hungarian experiences are reported. In the Hungarian Congenital Malformation Register use of the anticonvulsants diazepam and phenobarbiturates during pregnancy was determined in infants delivered with cleft lip with or without cleft palate, posterior cleft palate and, as a control, anencephaly and spina bifida. The teratogenic effect of diphenyl-hydantoin was confirmed, while that of diazepam and phenobarbital was not supported.

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