PMID: 3744196May 1, 1986Paper

A teratology study on vomitoxin (4-deoxynivalenol) in rabbits

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
K S KheraG Angers

Abstract

Diets containing 4-deoxynivalenol (vomitoxin) of greater than 98% purity were fed to rabbits on days 0-30 of gestation. The dietary concentrations of 4-deoxynivalenol were 0, 0.00075, 0.0015, 0.003, 0.006, 0.012 and 0.024% and the daily intakes of deoxynivalenol were 0, 0.3, 0.6, 1.0, 1.6, 2.0 and 1.8 mg/kg body weight/day, respectively. A pair-fed group was given a feed intake equivalent to that in the 1.6-mg/kg group. The only significant effects that were observed in foetuses examined at day 30 of gestation occurred only at doses that caused reductions in both the body weight and feed intake of does. The foetal effects consisted of a 100% incidence of resorption in the 1.8- and 2.0-mg/kg groups and decreased mean foetal weight in the 1.0- and 1.6-mg/kg and pair-fed groups. The doses that did not appear to be maternotoxic (0.6 and 0.3 mg/kg) did not show any adverse effects in foetuses at term. Vomitoxin given in the diet during pregnancy failed to show any evidence of teratogenic potential in rabbits.

References

Jun 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R E Morrissey
Jul 1, 1984·Toxicology and Applied Pharmacology·K S KheraP M Scott
Oct 1, 1982·Bulletin of Environmental Contamination and Toxicology·K S KheraT Kuiper-Goodman

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Citations

Jan 1, 1988·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K S Khera, C Whalen
Feb 22, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Robert L SprandoDennis I Ruggles
Mar 15, 2005·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·James J Pestka, Alexa T Smolinski
Nov 14, 2015·Journal of Food Science·Hyun Jung Lee, Dojin Ryu
Sep 25, 2016·Archives of Toxicology·Delphine PayrosIsabelle P Oswald
Dec 6, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Thomas F X CollinsDennis I Ruggles
Aug 7, 2018·The Journal of Pharmacy and Pharmacology·Pinxuan HuangMeihua Yang
Sep 11, 2017·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Lutz Edler
Jan 4, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Madelyn C HuangDori Germolec

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