PMID: 40259Jul 1, 1979

A test of anxiety that distinguishes between the actions of benzodiazepines and those of other minor tranquilisers and of stimulants

Pharmacology, Biochemistry, and Behavior
S E File, J R Hyde


The effects of minor tranquilisers and of stimulant drugs were studied in the Social Interaction test of anxiety in which the illuminance and unfamiliarity of the test arena are manipulated. Acute administration of sodium phenobarbitone (25 mg/kg) was without effect. Acute administration of sodium phenobarbitone (35 mg/kg) and of meprobamate (60 mg/kg) produced sedation: both locomotor activity and social interaction were reduced. On the other hand, amphetamine sulphate (2 mg/kg) and caffeine citrate (20 mg/kg) reduced social interaction, but increased locomotor activity. Chronic administration dissociated the pattern of results produced by sodium phenobarbitone (35 mg/kg) from that produced by flurazepam (0.5 mg/kg). With chronic treatment (5 days) neither drug reduced motor activity, but whereas phenobarbitone increased social interaction regardless of the test illuminance and unfamiliarity, the increase produced by flurazepam was limited to the more stressful test conditions, i.e., when the arena was unfamiliar or brightly lit.


Jan 1, 1986·Psychopharmacology·S E File, S Pellow
Jan 1, 1983·Psychopharmacology·J P PascoeB S Kapp
Jan 1, 1984·Psychopharmacology·J M Witkin
Jan 1, 1982·Psychopharmacology·M R Landauer, R L Balster
Jan 1, 1993·Psychopharmacology·R Trullas, P Skolnick
Jan 10, 1989·European Journal of Pharmacology·H A BaldwinS E File
Dec 17, 1991·European Journal of Pharmacology·L NegriF Angelucci
Jun 24, 1993·European Journal of Pharmacology·D A GolombekD P Cardinali
Jul 6, 1993·European Journal of Pharmacology·J D BrioniM W Decker
Oct 1, 1982·Neuropharmacology·S E FileD J Nutt
Dec 1, 1984·Physiology & Behavior·W R Holloway, D H Thor
Jun 1, 1984·Physiology & Behavior·C H Beck, H L Chow
Aug 1, 1980·Pharmacology, Biochemistry, and Behavior·J N Crawley, F K Goodwin
Jul 1, 1981·Pharmacology, Biochemistry, and Behavior·R B MurrayR J Tallarida
Nov 1, 1985·Pharmacology, Biochemistry, and Behavior·S E File, S Pellow
Jul 1, 1985·Pharmacology, Biochemistry, and Behavior·R OettingerK Bättig
Jan 1, 1985·Pharmacology, Biochemistry, and Behavior·S Gerhardt, J M Liebman
May 1, 1985·Pharmacology, Biochemistry, and Behavior·G B Freeman, J B Thurmond
Aug 1, 1988·Pharmacology, Biochemistry, and Behavior·S E FileL J Wilks
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·H A Baldwin, S E File
Oct 1, 1994·Pharmacology, Biochemistry, and Behavior·S LightowlerI F Tulloch
Aug 1, 1996·Pharmacology, Biochemistry, and Behavior·P C YannielliD P Cardinali
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·S Pellow
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·D Treit
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·R A Shephard
Jan 1, 1990·Pharmacology & Therapeutics·R G Lister
Dec 1, 1979·Journal of Affective Disorders·S E File, J R Hyde


Jan 1, 1978·British Journal of Pharmacology·S E File, J R Hyde
Jan 1, 1979·Physiology & Behavior·S E File, S V Vellucci
Aug 22, 1973·Psychopharmacologia·L A Syme, G J Syme

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