A Test Utilization Approach to the Diagnostic Workup of Isolated Eosinophilia in Otherwise Morphologically Unremarkable Bone Marrow: A Single Institutional Experience

American Journal of Clinical Pathology
Hong FangKaaren K Reichard

Abstract

Determine ancillary test utilization for the workup of isolated eosinophilia in otherwise morphologically unremarkable bone marrow (BM). We evaluated BM ancillary testing performed in cases with isolated eosinophilia and otherwise morphologically unremarkable BM. Cases with abnormal morphology (eg, dysplasia, basophilia) and/or findings suggestive of a disorder (eg, unexplained thromboses, lymphoma) are specifically excluded. A total of 132 cases met inclusion criteria. Ten cases had an ancillary testing abnormality that warranted a more specific hematologic diagnosis: four cases of lymphocytic variant of hypereosinophilic syndrome, three cases of myeloid neoplasm with PDGFRA rearrangement, and one case each of myeloid neoplasm with PDGFRB rearrangement, chronic eosinophilic leukemia, and morphologically occult systemic mastocytosis. No cases revealed a cryptic PDGFRB or BCR/ABL1 rearrangement or JAK2 V617F mutation. Findings from our institutional experience support initial testing in isolated eosinophilia with otherwise unremarkable BM to include PDGFRA rearrangement, tryptase/CD25 immunohistochemistry, cytogenetics, and T-cell flow cytometry/receptor gene rearrangement. This approach achieves diagnostic quality and test util...Continue Reading

References

Jun 6, 2002·Lancet·Gerald J GleichJoseph H Butterfield
Jul 20, 2002·Leukemia Research·Patricia AultHagop Kantarjian
Sep 8, 2004·Cancer Genetics and Cytogenetics·Patricia T GreippAyalew Tefferi
May 10, 2006·British Journal of Haematology·Ayalew TefferiAnimesh Pardanani
Sep 18, 2007·Immunology and Allergy Clinics of North America·Florence RoufosseMichel Goldman
Feb 21, 2008·American Journal of Clinical Pathology·Curtis A HansonRhett P Ketterling
Jun 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Srdan VerstovsekHagop Kantarjian
Jun 7, 2011·Leukemia Research·Celalettin UstunCem Akin
Mar 31, 2012·The Journal of Allergy and Clinical Immunology·Peter ValentGerald J Gleich
May 13, 2015·Blood·Amy D Klion
Dec 1, 2013·Surgical Pathology Clinics·Ryan C Johnson, Tracy I George
Mar 13, 2016·European Journal of Internal Medicine·Grzegorz Helbig
May 14, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sa A WangAttilio Orazi
May 28, 2016·Haematologica·Marketa ZaliovaJan Zuna
Sep 30, 2016·Archives of Pathology & Laboratory Medicine·Daniel F Boyer
Dec 29, 2016·Blood·Andreas Reiter, Jason Gotlib
Jan 24, 2017·British Journal of Haematology·Nauman M ButtUNKNOWN British Committee for Standards in Haematology
Jul 5, 2017·Hematology/oncology Clinics of North America·Jason Gotlib
Aug 2, 2017·The Journal of Allergy and Clinical Immunology. in Practice·Paneez KhouryAmy D Klion

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Citations

Oct 15, 2019·American Journal of Clinical Pathology·Estafani RivasWei Cui
Mar 12, 2020·Cytometry. Part B, Clinical Cytometry·Zhihong HuSa A Wang

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