Abstract
Tumor protein D52-like proteins (TPD52) are small coiled-coil motif bearing proteins that were first identified in breast cancer. TPD52 and related proteins have been implicated in cell proliferation, apoptosis, and vesicle trafficking. To date, three human TPD52 members had been identified, named hD52 (TPD52), hD53 (TPD52L1), and hD54 (TPD52L2). The most important characteristic of the protein family is a highly conserved coiled-coil motif that is required for homo- and heteromeric interaction with other TPD52-like proteins. Herein, we identified a novel TPD52-like sequence (TPD52L3, or hD55) in human testis using cDNA microarray. Sequence analysis of the deduced protein suggests that hD55 contains a coiled-coil motif and is highly conserved compared with other TPD52-like sequences. Yeast two-hybrid and GST pull-down assays revealed that hD55 interacts with hD52, hD53, hD54, and itself. cDNA microarray detection found that hD55 was expressed at 5.6-fold higher levels in adult testis than in fetal testis. Additionally, the expression profile shows that hD55 is testis-specific, indicating a potential role for hD55 in testis development and spermatogenesis.
References
Jul 21, 1988·Nature·C SantoroR Tjian
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·B BergerP S Kim
Aug 16, 1996·The Journal of Biological Chemistry·J A ParenteC S Chew
Aug 1, 1996·Genomics·J A ByrneP Basset
Nov 29, 1996·The Journal of Biological Chemistry·V ProuxM Marx
Dec 6, 1996·The Journal of Biological Chemistry·G E GroblewskiJ A Williams
Mar 4, 1998·Oncogene·J A ByrneP Gunning
Dec 5, 1998·Biochimica Et Biophysica Acta·C R NourseJ A Byrne
Aug 5, 2000·Genes, Chromosomes & Cancer·R L BalleineJ A Byrne
Sep 11, 2001·Genomics·S H WilsonJ A Byrne
Oct 12, 2001·Biochemical and Biophysical Research Communications·P SathasivamJ A Byrne
May 25, 2002·Molecular Human Reproduction·Jiahao ShaUNKNOWN Spermatogenesis study group
Jul 10, 2002·The Journal of Biological Chemistry·Diana D H ThomasGuy E Groblewski
Oct 9, 2002·Genome Research·Lewis Y GeerStephen H Bryant
Oct 12, 2002·The Biochemical Journal·Véronique Proux-GillardeauxMaria Marx
Aug 2, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kala M KasparGuy E Groblewski
Sep 10, 2003·Journal of Molecular Biology·Rose BoutrosJennifer A Byrne
Oct 28, 2003·Molecular Reproduction and Development·Mark S FoxRenee A Reijo Pera
Feb 6, 2004·The Journal of Biological Chemistry·Sayeon ChoByoung-Chul Park
Mar 5, 2004·Cancer Research·Ruoxiang WangLeland W K Chung
Jun 3, 2004·Cancer Research·Mark A RubinArul M Chinnaiyan
Nov 24, 2004·Biochemical and Biophysical Research Communications·Rose BoutrosJennifer A Byrne
Jun 30, 2005·International Journal of Cancer. Journal International Du Cancer·Jennifer A ByrneAnna Defazio
Sep 29, 2005·Nature·Jean-François RualMarc Vidal
Citations
Sep 21, 2013·Molecular Biology Reports·Juan ZhouYanhong Li
Jul 1, 2008·Molecular Biotechnology·Qinghuai LiuJianmin Li
Mar 27, 2013·Cellular Oncology (Dordrecht)·Yoshiki MukudaiSatoru Shintani
Oct 4, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Catherine S ChewHan Zhang
Oct 13, 2011·Journal of Assisted Reproduction and Genetics·Debbie MontjeanMoncef Benkhalifa
Mar 12, 2009·Journal of Cancer Research and Clinical Oncology·Yuxin ChenJianmin Li
May 10, 2007·International Journal of Radiation Biology·A H SimsR B Clarke
Apr 25, 2012·Science China. Life Sciences·Yan XiaLong Yu
Mar 28, 2008·Science in China. Series C, Life Sciences·Li ZhuJianHua Ma
Feb 10, 2009·Vaccine·Saied MirshahidiRuth M Ruprecht
Sep 5, 2009·Brain Research·Jacqueline VazquezMary Ann Greco
Sep 30, 2014·Cell Biology International·Yongchun HeSihui Chen
Sep 29, 2011·Cell Cycle·Tsutomu MoriHideo Kochi
Sep 28, 2013·Oncoimmunology·Jennifer D BrightRobert K Bright
Jan 30, 2015·Cancer Biotherapy & Radiopharmaceuticals·Mei YangShan Wu
Nov 30, 2006·Molecular Reproduction and Development·Wenxian ZengIna Dobrinski
Mar 17, 2017·The Biochemical Journal·Hiromi MotohashiTatsuo Shirota
Nov 2, 2019·The Journal of Cell Biology·Gabrielle LarocqueStephen J Royle
Oct 22, 2016·Oncotarget·Chunwen TanShu Zheng
Aug 18, 2018·Experimental and Therapeutic Medicine·Xiaojun Zhao, Jiusheng Chu
Mar 25, 2017·International Journal of Oncology·Kosuke KatoTatsuo Shirota
Aug 12, 2017·BioMed Research International·Chihiro ItoTatsuo Shirota
Feb 23, 2007·Molecular Cancer Research : MCR·Jennifer D LewisRobert K Bright
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mona ShehataJennifer A Byrne
Jul 5, 2021·Cell & Bioscience·Yuzo AbeTatsuo Shirota
Jul 22, 2021·The Journal of Cell Biology·Gabrielle LarocqueStephen J Royle
Aug 31, 2021·Frontiers in Oncology·Qin HongBo Wen