PMID: 3762425Sep 1, 1986Paper

A theoretical analysis of the effect of the particulate nature of blood on oxygen release in capillaries

Microvascular Research
W J Federspiel, A S Popel

Abstract

A theoretical model is developed to investigate the role played by the particulate (two-phase) nature of blood on oxygen (O2) release in capillary-size vessels. Red cells flowing in single-file suspension through capillaries are modelled as evenly spaced, hemoglobin (Hb)-containing circular particles in a rectangular channel (two-dimensional case) or axisymmetric spheres in a circular tube (three-dimensional case). The model includes the free and Hb-facilitated transport of O2 and Hb-O2 kinetics inside the particles, diffusion of free O2 in the suspending phase, and a specified O2 tension at the capillary wall that drives the release of O2 from the particles as they traverse the capillary. The results are expressed in the form of a capillary mass transfer coefficient, an inverse resistance, that relates the spatial average flux of O2 out of the capillary to a driving force for O2 release. The results indicate that this coefficient depends significantly on particle spacing and clearance (channel size relative to particle size) but not significantly on the O2 tension at the capillary wall nor the eccentricity of the particles in the channel. It is also found that the capillary mass transfer coefficient can be several times smalle...Continue Reading

References

Jan 1, 1979·Seminars in Thrombosis and Hemostasis·J S Finlayson
Feb 1, 1985·Biophysical Journal·A ClarkG R Cokelet
Jul 1, 1970·Microvascular Research·J Aroesty, J F Gross
May 1, 1965·Journal of Theoretical Biology·F M Snell
Mar 1, 1966·The Journal of General Physiology·K H Keller, S K Friedlander
Jan 1, 1983·Annals of Biomedical Engineering·P T Baxley, J D Hellums
Aug 1, 1982·Pflügers Archiv : European journal of physiology·S R KayarN Banchero
Jan 1, 1980·Annals of Biomedical Engineering·B V Sheth, J D Hellums

❮ Previous
Next ❯

Citations

Jan 1, 1991·Anatomy and Embryology·J P van GroningenL H Testers
Jan 1, 1989·Annals of Biomedical Engineering·M SharanA S Popel
Jan 1, 1996·Annals of Biomedical Engineering·J D HellumsN Ohshima
Jul 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T StandlJ Schulte am Esch
Jun 16, 2006·Annals of Biomedical Engineering·Ranjan K Dash, James B Bassingthwaighte
Aug 24, 2012·Annals of Biomedical Engineering·James B BassingthwaighteKalyan Vinnakota
Mar 1, 1992·Mathematical Biosciences·M Sharan, S Selvakumar
Jul 1, 1993·Mathematical Biosciences·C H Wang, A S Popel
Feb 1, 1995·Mathematical Biosciences·C BosT Oostendorp
Mar 3, 2004·Free Radical Biology & Medicine·John S OlsonDouglas D Lemon
Sep 22, 2000·Mathematical Biosciences·C D EggletonA S Popel
Dec 26, 2001·Computer Methods and Programs in Biomedicine·Richard P BeyerAndreas J Deussen
Jun 6, 2000·Advanced Drug Delivery Reviews·R M Winslow
Mar 28, 2003·Respiratory Physiology & Neurobiology·Russell T HeppleMichael C Hogan
Jan 15, 2013·Nature Medicine·Alexandre ParpaleixSerge Charpak
Apr 12, 2000·Acta Physiologica Scandinavica·P D Wagner
Apr 12, 2000·Acta Physiologica Scandinavica·K E ConleyR S Richardson
Jun 20, 2001·Acta Physiologica Scandinavica·P K LundeO M Sejersted
Dec 21, 2000·British Journal of Haematology·R M Winslow
Jun 26, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kevin K Parker, Donald E Ingber
Oct 5, 2010·Acta Physiologica·R K Pradhan, V S Chakravarthy
Feb 2, 2011·Acta Physiologica·R N Pittman
Aug 3, 2005·Journal of Biomechanical Engineering·Ali A Merrikh, José L Lage
Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Andrew C Betik, Russell T Hepple
Mar 12, 1999·Annual Review of Medicine·R M Winslow
Sep 14, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jessica SpiresNicola Lai
May 1, 2009·American Journal of Physiology. Renal Physiology·Jing ChenAurélie Edwards
Jun 9, 2012·Journal of Applied Physiology·Daniel M HiraiDavid C Poole
Oct 1, 1995·The Journal of Clinical Investigation·R S RichardsonP D Wagner
Oct 3, 1998·The Japanese Journal of Physiology·E Takahashi, K Doi
Dec 6, 2006·The Journal of Chemical Physics·Shashwati Roy MajumderSwapan K Ghosh
May 1, 1995·Intensive Care Medicine·P D Wagner
May 8, 2001·Annals of Biomedical Engineering·D A Beard, J B Bassingthwaighte
Feb 9, 2016·Respiratory Physiology & Neurobiology·Kenneth H McKeeverDavid C Poole
Jan 8, 2005·The Journal of Physiology·Paul McDonoughDavid C Poole

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.