A theoretical and experimental analysis of formulation and device parameters affecting solution MDI size distributions

Journal of Pharmaceutical Sciences
Stephen W Stein, Paul B Myrdal

Abstract

The influence of formulation and device configurations on the initial droplet and residual particle size distribution from solution MDIs was theoretically and experimentally examined. Aerodynamic size distribution tests were conducted to characterize the size distribution of the residual particles formed when a solution MDI is actuated. The measured size distributions were approximately log-normally distributed, and did not show evidence of a secondary large particle mode. Theoretical relationships were developed to relate the residual particle size distribution to the initial size distribution of the atomized droplets. The residual particle size distribution was shown to be proportional to the nonvolatile concentration to the one-third power. Ethanol concentration, propellant type, valve size, and actuator orifice diameter were all shown to affect the initial droplet size distribution. Deposition of drug in the mouthpiece and USP inlet affect the measured size distribution during aerodynamic particle size measurements. Although there is a significant increase in the size of initial droplets as ethanol concentration increases, there is only a minor increase in the size of the residual particles measured when the USP Inlet is us...Continue Reading

References

Apr 1, 1969·Journal of Pharmaceutical Sciences·G P PolliM H Yunker
Jun 27, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·P H Howarth
Jun 26, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Stephen W SteinTyler J Beck
Jun 26, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Abhishek GuptaPaul B Myrdal
Mar 6, 2004·Drug Development and Industrial Pharmacy·Venkatesh NainiJoel Sequeira
Nov 4, 2004·Drug Development and Industrial Pharmacy·Paul B MyrdalAbhishek Gupta

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Citations

Aug 6, 2013·International Journal of Pharmaceutics·Poonam ShethPaul B Myrdal
Jan 2, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Paul B MyrdalStephen W Stein
Sep 29, 2011·Future Medicinal Chemistry·David Lechuga-BallesterosSarvajna K Dwivedi
Aug 29, 2013·BioMed Research International·Imran Y Saleem, Hugh D C Smyth
Feb 19, 2016·Pharmaceutical Research·Nicholas Mason-SmithDamon Honnery
Dec 17, 2014·Expert Opinion on Drug Delivery·James W IveyWarren H Finlay
May 11, 2007·Expert Opinion on Drug Delivery·David Lewis
Nov 22, 2005·Expert Opinion on Drug Delivery·Hugh D C Smyth
Nov 22, 2005·Expert Opinion on Drug Delivery·Philippe Rogueda
Nov 3, 2011·International Journal of Pharmaceutics·Stephen W SteinPaul B Myrdal
Nov 3, 2011·International Journal of Pharmaceutics·Parthiban SelvamSandro R P da Rocha
Aug 11, 2015·Molecular Pharmaceutics·Stephen W SteinPaul B Myrdal
Dec 21, 2013·AAPS PharmSciTech·Stephen W SteinPaul B Myrdal
May 9, 2014·AAPS PharmSciTech·Alaa S TulbahDaniela Traini
Jan 24, 2014·AAPS PharmSciTech·Paul B MyrdalStephen W Stein
Feb 15, 2014·International Journal of Pharmaceutics·James W IveyReinhard Vehring
Jul 28, 2020·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Felix C WiegandtGerhard Pohlmann
Jun 5, 2019·AAPS PharmSciTech·Philip J KuehlRobert O Williams
May 4, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Morteza YousefiJiyuan Tu

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