A theoretical compartment model for antigen kinetics in the skin

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Anne M RömgensCees W J Oomens

Abstract

The skin is a promising location for vaccination with its abundant population of antigen capturing and presenting cells. The development of new techniques, such as the use of microneedles, can facilitate the delivery of vaccines into the skin. In recent years, many different types of microneedle arrays have been designed. However, their geometry and arrangement within an array may be optimized to trigger sufficient antigen presenting cells. A computational model can support the rational design of microneedle arrays. Therefore, the aim of the current study was to describe the distribution and kinetics of a delivered antigen within the skin using a theoretical compartment model, which included binding of antigens to receptors and their uptake by cells, and to determine which parameters should be measured to validate the model for a specific application. Multiple simulations were performed using a high and low antigen delivery dose and a range of values for the rate constants. The results indicated that the cells were highly saturated when a high dose was applied, while for a low dose saturation was only reached in 5% of the simulations. This was caused by the difference in the ratio between the administered dose and the available...Continue Reading

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Citations

Aug 25, 2016·Computer Methods in Biomechanics and Biomedical Engineering·Anne M RömgensCees W J Oomens
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kevin Ita
Dec 6, 2016·Journal of Drug Targeting·Yukako ItoKanji Takada
May 10, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jessica C JoyceMark R Prausnitz

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