A theoretical model for transdermal drug delivery from emulsions and its dependence upon formulation

Journal of Pharmaceutical Sciences
Fernando P Bernardo, Pedro M Saraiva

Abstract

This article presents a theoretical model of transdermal drug delivery from an emulsion-type vehicle that addresses the vehicle heterogeneity and incorporates the prediction of drug transport parameters as function of the vehicle composition. The basic mass transfer model considers interfacial and diffusion resistances within the emulsion and partition/diffusion phenomena across two skin compartments in series. Drug transport parameters are predicted as follows: partition coefficients are derived from regular solutions theory, drug diffusivity in the continuous phase is computed from a free volume theory with segmental motion, and permeability of the surfactant layer around droplets is estimated based on a free surface area model. These relationships are incorporated within the basic mass transfer model, so that the overall model is able to predict temporal profiles of drug release from the vehicle and of drug concentration in plasma, as a function of vehicle composition. In this way, the proposed model provides a sound physicochemical basis to support the development of new formulations and the planning of experiments. A simulated case study regarding a nitroglycerin ointment is presented in detail, illustrating how thermodyna...Continue Reading

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Citations

Jul 4, 2012·Advanced Drug Delivery Reviews·Dominik SelzerDirk Neumann
Jan 7, 2010·Drug Development and Industrial Pharmacy·Chengwen MaoXiangliang Yang
Mar 19, 2014·Journal of Pharmaceutical Sciences·Dominique Jasmin LunterRolf Daniels
Aug 14, 2012·Medicinal Research Reviews·Josef Jampilek, Katerina Brychtova
Apr 19, 2016·Annual Review of Chemical and Biomolecular Engineering·Lei ZhangRafiqul Gani
Mar 17, 2020·Pharmaceutical Development and Technology·Dimple ModiGossett Campbell
Jul 22, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mahadevabharath R SomayajiLaurent Simon

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