PMID: 16532628Mar 15, 2006Paper

A theoretical model of enlarging intracranial fusiform aneurysms

Journal of Biomechanical Engineering
Seungik BaekJ D Humphrey

Abstract

The mechanisms by which intracranial aneurysms develop, enlarge, and rupture are unknown, and it remains difficult to collect the longitudinal patient-based information needed to improve our understanding. We submit, therefore, that mathematical models hold promise by allowing us to propose and test competing hypotheses on potential mechanisms of aneurysmal enlargement and to compare predicted outcomes with limited clinical information--in this way, we may begin to narrow the possible mechanisms and thereby focus experimental studies. In this paper, we present a constrained mixture model of evolving thin-walled, fusiform aneurysms and compare multiple competing hypotheses with regard to the production, removal, and alignment of the collagen that provides the structural integrity of the wall. The results show that this type of approach has the capability to infer potential means by which lesions enlarge and whether such changes are likely to produce a stable or unstable process. Such information can better direct the requisite histopathological examinations, particularly on the need to quantify collagen orientations as a function of lesion geometry.

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Citations

Jan 9, 2007·Biomechanics and Modeling in Mechanobiology·Gerard A Ateshian
Feb 24, 2007·Biomechanics and Modeling in Mechanobiology·D AmbrosiE S Di Martino
Mar 14, 2007·Biomechanics and Modeling in Mechanobiology·Niels J B DriessenFrank P T Baaijens
Aug 19, 2007·Biomechanics and Modeling in Mechanobiology·J D HumphreyA T Yeh
Dec 7, 2007·Biomechanics and Modeling in Mechanobiology·P N Watton, N A Hill
Jan 6, 2009·Biomechanics and Modeling in Mechanobiology·L CardamoneJ D Humphrey
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Nov 4, 2010·Biomechanics and Modeling in Mechanobiology·Jessica E Wagenseil
Nov 6, 2010·Biomechanics and Modeling in Mechanobiology·Shahrokh Zeinali-DavaraniSeungik Baek
May 10, 2007·Annals of Biomedical Engineering·J D HumphreyL E Niklason
Apr 8, 2009·Annals of Biomedical Engineering·J F EberthJ D Humphrey
Jul 29, 2010·Annals of Biomedical Engineering·R M Pedrigi, J D Humphrey
Mar 20, 2013·Annals of Biomedical Engineering·Samarth S RautEnder A Finol
Aug 4, 2009·Medical & Biological Engineering & Computing·Arturo Valentín, Jay D Humphrey
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Apr 12, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Shahrokh Zeinali-DavaraniSeungik Baek
Jun 8, 2010·International Journal of Computational Fluid Dynamics·J D Humphrey
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May 2, 2013·Proceedings. Mathematical, Physical, and Engineering Sciences·J S WilsonJ D Humphrey
Aug 7, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·A Valentín, J D Humphrey
Dec 3, 2008·Journal of Biomechanical Engineering·Martin Kroon, Gerhard A Holzapfel
Oct 17, 2009·Journal of Biomechanical Engineering·A Valentín, J D Humphrey
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Mar 19, 2014·Biomechanics and Modeling in Mechanobiology·Ganarupan SathaAnders Klarbring
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Jun 20, 2012·Mechanics Research Communications·A Valentín, G A Holzapfel
Dec 20, 2011·Mechanics of Materials : an International Journal·Igor Karšaj, Jay D Humphrey

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