A theoretical model of erosion and macromolecular drug release from biodegrading microspheres

Journal of Pharmaceutical Sciences
R P BatyckyD A Edwards

Abstract

A theoretical model is outlined for predicting the time evolution of total mass, mean molecular weight, and drug release for the case of a spherical bulk-eroding microsphere, prepared by a double emulsification procedure and containing a hydrophilic drug, such as a protein or peptide. Explicit analytical formulae are derived for calculating the time evolution of measurable macroscopic characteristics, such as drug release or mean molecular weight. Microsphere hydration, polymer erosion, and drug release phases are each described. Results indicate that polymer degradation by only random-chain scission or only end scission (or unzipping) cannot explain experimentally observed kinetics of particle mass loss and molecular weight change; thus, a combined model (incorporating both random and end scission) is proposed. A general methodology for determining the microscopic transport coefficients (such as polymer degradation rate constant or drug diffusion coefficient) from erosion and release data is outlined. This paradigm is applied to the specific case of 50:50 poly(D,L-lactic-co-glycolic acid (PLGA) microspheres encapsulating glycoprotein 120 (gp 120), a candidate AIDS vaccine. Predictions permit comparisons with experimental data ...Continue Reading

References

Jul 1, 1995·Pharmaceutical Research·S CalisP P DeLuca
Mar 18, 1994·Science·R GrefR Langer

❮ Previous
Next ❯

Citations

Mar 29, 2000·Journal of Biomedical Materials Research·L LuA G Mikos
Dec 18, 2001·Journal of Biomedical Materials Research·Moriah Nof, Lonnie D Shea
Apr 10, 2010·Annals of Biomedical Engineering·Nathan H DormerMichael S Detamore
Dec 11, 2008·Biomedical Microdevices·Gianni CiofaniSilvestro Micera
Aug 20, 2010·Pharmaceutical Research·Martin Körber
Apr 29, 2008·Theory in Biosciences = Theorie in Den Biowissenschaften·Ana BaratMartin Crane
Jun 7, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Akihiro MatsumotoHiroyuki Yoshino
Jul 8, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·M van de WeertD J Crommelin
Dec 5, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·T MoritaH Yoshino
Feb 13, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·S HirosueR Langer
Aug 23, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·X Huang, C S Brazel
Jul 14, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·H H ChiaJ Heller
Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Juan WangSteven P Schwendeman
Apr 1, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·D D HileM V Pishko
Jun 6, 2000·Advanced Drug Delivery Reviews·R LangerJ Hanes
Nov 14, 2002·International Journal of Pharmaceutics·Xiao HuangChristopher S Brazel
Jul 27, 2012·Environmental Science & Technology·Asha N SharmaM Todd Walter
May 21, 2010·Chemical Communications : Chem Comm·Inhar ImazDaniel Maspoch
Jun 3, 1999·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·J WangD A Edwards
Jul 13, 2006·Annual Review of Biomedical Engineering·Dennis E Discher, Fariyal Ahmed
Oct 24, 2012·AAPS PharmSciTech·Francesca SelminPatrick P DeLuca
Oct 24, 2012·International Journal of Nanomedicine·Bullo SaifullahSamer Hasan Hussein Al Ali
May 19, 2009·Journal of Materials Science. Materials in Medicine·Marco BiondiPaolo A Netti
Aug 23, 2011·Drug Development and Industrial Pharmacy·Paulo R R MinariniMaria Vitória L B Bentley
Jun 6, 2008·Expert Opinion on Drug Delivery·S Dean Allison
Aug 5, 2011·Drug Delivery·Fengliang CaoGuangxi Zhai
Oct 4, 2005·Journal of Drug Targeting·Sandrine BourgeoisElias Fattal
Dec 23, 2011·Journal of Pharmaceutical Sciences·Aurélie SchoubbenPatrick P Deluca
Jul 8, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nicholas A Peppas, Balaji Narasimhan
Dec 17, 2009·Journal of Pharmaceutical Sciences·Marina Sokolsky-PapkovCarolyn F Weiniger
Apr 7, 2004·Journal of Pharmaceutical Sciences·Tommy T ThomasRobert Langer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.